# US 10,478,482 B2 · Vaccines for prevention and treatment of tuberculosis

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- Number: US 10,478,482 B2
- Document ID: US10478482B2
- Status: Granted
- Kind: B2
- Application number: 16/285,353
- Filed: 2019-02-26
- Published: 2019-06-13
- Granted: 2019-11-19
- Earliest claimed: 2011-04-11
- Assignees: Alarum Development Ltd.
- Applicants: Markus Maeurer
- Inventors: Markus Maeurer
- Web page: https://patentgrep.com/patent/US10478482B2

## CPC

- A61K 39/04: Mycobacterium, e.g. Mycobacterium tuberculosis
- C07K 14/35: from Mycobacteriaceae (F)
- C12N 15/117: Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
- C12Q 1/48: involving transferase
- A61K 2039/522: {avirulent or attenuated}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- C12Q: MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES

## Abstract

The present invention provides new immunological compositions and vaccines comprising selected M. tuberculosis antigens and antigenic peptides as well as nucleic acids encoding said antigens for use in the prevention, prophylaxis and treatment of mycobacterial infection, especially tuberculosis. In particular the invention provides recombinant BCG based vaccines in which one or more of the selected M. tuberculosis antigens are over expressed. The invention further provides isolated peptides for use in methods for diagnosing, characterizing, or classifying mycobacterial infections.

## Claims

### Claim 1

A method of eliciting an immune response against Mycobacterium tuberculosis in a mammalian subject comprising the step of administering to said subject an immunological composition consisting essentially of a first isolated polypeptide of the amino acid sequence of SEQ ID NO: 1, a second isolated polypeptide of the amino acid sequence of SEQ ID NO: 2, and a third isolated polypeptide of the amino acid sequence of SEQ ID NO: 3 and at least one of a pharmaceutically acceptable carrier and an adjuvant.

### Claim 2 (depends on 1)

The method of claim 1, wherein the immunological composition is formulated for administration via different routes.