# US 10,478,478 B2 · Treatment of Raynaud's phenomenon using botulinum toxin type B

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- Number: US 10,478,478 B2
- Document ID: US10478478B2
- Status: Granted
- Kind: B2
- Application number: 15/941,089
- Filed: 2018-03-30
- Published: 2018-10-04
- Granted: 2019-11-19
- Earliest claimed: 2017-03-31
- Assignees: National University Corporation Gunma University
- Applicants: National University Corporation Gunma University
- Inventors: Sei-ichiro Motegi
- Web page: https://patentgrep.com/patent/US10478478B2

## CPC

- A61K 38/4893: {Botulinum neurotoxin (3.4.24.69)}
- A61K 9/0019: {Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00)}
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

An effective amount of botulinum toxin type B is administered to a subject in need thereof for treating Raynaud's phenomenon. Botulinum toxin type B may be in a form of an injection, and may be locally administered to a disease affected site, in a dose of 200 to 400 units per disease affected site.

## Claims

### Claim 1

A method of treating Raynaud's phenomenon, comprising administering a therapeutically effective amount of botulinum toxin type B to a subject in need thereof, wherein said botulinum toxin type B is injected to sites between fingers and at the external sides of metacarpophalangeal joints of the first and fifth fingers of the subject.

### Claim 2 (depends on 1)

The method according to claim 1, wherein said botulinum toxin type B is injected to the subject at a dose of 200 to 400 units per one injection.