Method for prophylaxis or treatment of erbb1 positive cancers using a variant peptidase d with reduced activity
AssigneeHealth Research, Inc.
InventorsYuesheng Zhang, Lu Yang, Yun Li, Arup Bhattacharya
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Abstract
Provided are compositions and methods for prophylaxis and/or therapy of ErbB1-positive cancer. The compositions include pharmaceutical preparations that contain isolated or recombinant or modified peptidase D (PEPD) proteins. The methods include prophylaxis and/or therapy of ErbB1-positive cancer by administering a PEPD to an individual who has or is at risk for developing ErbB1-positive cancer.
Claims5
A method for prophylaxis or therapy of ErbB1-positive cancer in an individual comprising administering to the individual an effective amount of a composition comprising peptidase D (PEPD), the PEPD comprising the sequence of SEQ ID NO:1 with a mutation of G278, such that growth of the ErbB1-positive cancer is inhibited.
Dependencies are inferred from the claim text.