# US 10,478,467 B2 · Methods and compositions addressing depressed mood

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 10,478,467 B2
- Document ID: US10478467B2
- Status: Granted
- Kind: B2
- Application number: 16/019,039
- Filed: 2018-06-26
- Published: 2018-10-25
- Granted: 2019-11-19
- Earliest claimed: 2014-06-13
- Assignees: Centre for Addiction and Mental Health
- Applicants: Centre for Addiction and Mental Health
- Inventors: Jeffrey H. Meyer
- Web page: https://patentgrep.com/patent/US10478467B2

## CPC

- A61K 36/45: Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
- A61K 31/197: the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid (carnitine A61K31/205)
- A61K 31/405: Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
- A61K 36/315: Isatis, e.g. Dyer's woad
- A61P 25/24: Antidepressants
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A method for the treatment or prophylaxis of depressed mood is described, for subjects with increased MAO-A levels, subjects prone to excessive crying, or beyond 5-days postpartum. The subject is administered an antioxidant source on at least the first day of a 3 to 5 day regime; a tryptophan composition on the evening of the penultimate treatment day, simultaneously or following the antioxidant source; and a tyrosine composition the day after the tryptophan composition, on the final treatment day. The antioxidant source may comprise blueberries or another anthocyanin-containing fruit, vegetable, nut, legume, or a juice or extract thereof. Individuals with depressed mood due to perimenopause, due to an alcohol use disorder or withdrawal therefrom, or who are in a postpartum period up to or beyond 18-months, may benefit from the treatment regime. The described method can reduce the likelihood of advancing from depressed mood to postpartum depression in the postpartum period.

## Claims

### Claim 1

A method for treatment or prophylaxis of depressed mood in a subject experiencing excessive crying at up to 18-months postpartum, comprising administering to a subject in need thereof:
an antioxidant source once daily on at least day-1 of a treatment regime of from 3 to 5 days; wherein the antioxidant source comprises an anthocyanin-containing fruit, vegetable, nut, legume, or a juice or extract thereof, and has an ORAC value of at least about 3000 μmol TE/serving;
a tryptophan composition on the evening of the penultimate day of the treatment regime, simultaneously or following the antioxidant source, said tryptophan composition comprising from 1.0 g to 5.0 g of L-tryptophan per serving in free amino acid form, and acceptable diluents; and
a tyrosine composition on the final day of the treatment regime, said tyrosine composition comprising from 2.0 g to 50 g of L-tyrosine per serving in free amino acid form, and acceptable diluents.

### Claim 2 (depends on 1)

The method of claim 1, wherein the antioxidant source comprises grapes; berries; citrus fruit; pomegranate; tomato; squash; carrot; sweet potato; a dark green vegetable; a beet; a leafy vegetable; a Brassica oleracea vegetable such as cabbage, broccoli, cauliflower, kale, Brussels sprouts, savoy, or Chinese kale; a pepper; a melon; pineapple; lentils; a plant oil; a tree nut; and/or a juice, extract, or isolated antioxidant compound therefrom.

### Claim 3 (depends on 1)

The method of claim 1 wherein the antioxidant source comprises blueberries, blueberry juice, blueberry extract or a combination thereof.