# US 10,478,466 B1 · Topical vasodilator composition

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- Number: US 10,478,466 B1
- Document ID: US10478466B1
- Status: Granted
- Kind: B1
- Application number: 16/158,363
- Filed: 2018-10-12
- Granted: 2019-11-19
- Earliest claimed: 2015-02-13
- Applicants: Peter Kennedy; Carolyn Shawn Murphy
- Inventors: Peter Kennedy; Carolyn Shawn Murphy
- Web page: https://patentgrep.com/patent/US10478466B1

## CPC

- A61K 36/258: Panax (ginseng)
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 9/06: Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)}
- A61K 36/28: Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A61K 47/18: Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K 47/22: Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
- A61K 47/34: Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers (A61K47/10 takes precedence)
- A61K 47/44: Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin (synthetic glycerides, e.g. medium-chain triglycerides, A61K47/14)
- A61P 9/08: Vasodilators for multiple indications
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A topical composition comprising from about 0.05% to about 10.0% by weight of Arnica oil, from about 5.0% to about 20.0% by weight of a notoginseng herb comprising dammarane-type ginsenosides, from about 0.05% to about 10% by weight of a compound comprising cyclopentasiloxane, dimethicone crosspolymer, dimethicone/vinyl dimethicone crosspolymer, dimethiconol, and a cosmetically acceptable aqueous carrier.

## Claims

### Claim 1

A topical composition comprising:
(a) from about 0.05% to about 10.0% by weight of Arnica oil;
(b) from about 5.0% to about 20.0% by weight of a notoginseng herb comprising dammarane-type ginseno sides;
(c) from about 0.05% to about 10% by weight of a compound comprising cyclopentasiloxane, dimethicone crosspolymer, dimethicone/vinyl dimethicone crosspolymer, and dimethiconol;
(d) from about 0.05% to about 5.0% by weight cetearyl alcohol;
(e) from about 0.75% to about 0.85% by weight of a compound formed from diazolidinyl urea (“DU”) and iodopropynyl butylcarbamate (“IPBC”), wherein the ratio of DU to IPBC is substantially 99% to 1% by weight;
(f) about 0.05% to about 2.5% by weight of dimethyl sulfone;
(g) about 0.25% weight of phytonadione; and
a cosmetically acceptable aqueous carrier, wherein upon a topical application of the composition to a skin contusion region, such application promotes vasodilatation in the region and dissipation of the contusion, wherein the notoginseng herb comprising dammarane-type ginsenosides is selected from the group consisting of, Panax quinquefolius, Panax vietnamensis, and Panax notoginseng and mixtures thereof.

### Claim 2 (depends on 1)

The topical composition according to claim 1, in which the cetearyl alcohol comprising from about 1.05% to about 4.0% by weight cetearyl alcohol.

### Claim 3 (depends on 1)

The topical composition according to claim 1, further comprising from about 0.05% to about 8.0% by weight dimethicone.

### Claim 4 (depends on 3)

The topical composition according to claim 3, further comprising from about 0.01% to about 2.5% by weight of cyclopentasiloxane.

### Claim 5 (depends on 1)

The topical composition according to claim 1, further comprising from about 0.01% to about 2.5% by weight of cyclopentasiloxane.

### Claim 6 (depends on 5)

The topical composition according to claim 5, further comprising from about 2.75% to about 3.25% by weight of glycerin.

### Claim 7 (depends on 1)

The topical composition according to claim 1, further comprising about 0.10% by weight of vitamin E.

### Claim 8 (depends on 1)

The topical composition according to claim 1, in which the cosmetically acceptable aqueous carrier is in the form of an ointment.

### Claim 9 (depends on 1)

The topical composition according to claim 1, in which the cosmetically acceptable aqueous carrier is in the form of a cream.

### Claim 10 (depends on 1)

The topical composition according to claim 1, in which the cosmetically acceptable aqueous carrier is in the form of a gel.

### Claim 11 (depends on 1)

The topical composition according to claim 1, in which the cosmetically acceptable aqueous carrier is in the form of a lotion.

### Claim 12 (depends on 1)

The topical composition according to claim 1, in which the cosmetically acceptable aqueous carrier is in the form of a paste.

### Claim 13 (depends on 1)

The topical composition according to claim 1, further comprising liposomes, and/or micelles, and/or microspheres, wherein the liposomal preparation include cationic, and/or anionic, and/or neutral preparations.