# US 10,478,464 B2 · Compositions and methods of use

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- Number: US 10,478,464 B2
- Document ID: US10478464B2
- Status: Granted
- Kind: B2
- Application number: 12/687,769
- Filed: 2010-01-14
- Published: 2010-08-19
- Granted: 2019-11-19
- Earliest claimed: 2009-01-14
- Assignees: Kirit Shah
- Applicants: Vipul C. Chitalia; Daniel Prabakaran; Ajit Bharti; Gamini S. Jayatilake; Xiong Fu
- Inventors: Vipul C. Chitalia; Daniel Prabakaran; Ajit Bharti; Gamini S. Jayatilake; Xiong Fu
- Web page: https://patentgrep.com/patent/US10478464B2

## CPC

- A61K 36/11: Pteridophyta or Filicophyta (ferns)
- A61K 31/20: having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 1/16: for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A61P 11/00: Drugs for disorders of the respiratory system
- A61P 35/00: Antineoplastic agents
- A61P 35/02: specific for leukemia
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

This invention relates to the use of plant extracts, compositions thereof, and compounds isolated from plant extracts or obtained from synthetic means thereof, for the treatment of diseases, disorders or symptoms thereof (e.g., proliferation disorders, cancer).

## Claims

### Claim 1

A method of treating cancer in a subject comprising administering to the subject a composition comprising an effective amount of 8-hydroxyhexadecanoic acid, or a salt thereof, thereby treating said cancer;
wherein said cancer is a lung cancer.

### Claim 2

A method of treating cancer in a subject comprising administering to the subject a composition comprising an effective amount of 8-hydroxyhexadecanoic acid, or a salt thereof, thereby treating said cancer;
wherein said cancer is a lung cancer;
wherein said lung cancer is a non-small cell lung cancer.

### Claim 3

A method of treating cancer in a subject comprising administering to the subject a composition comprising an effective amount of 8-hydroxyhexadecanoic acid, or a salt thereof, thereby treating said cancer;
wherein said cancer is a lung cancer;
wherein said lung cancer is mediated by HOP-92 or NCI-H460 cancer cells.

### Claim 4

A method of treating cancer in a subject comprising administering to the subject a composition comprising an effective amount of 8-hydroxyhexadecanoic acid, or a salt thereof, thereby treating said cancer;
wherein said cancer is leukemia.

### Claim 5

A method of treating cancer in a subject comprising administering to the subject a composition comprising an effective amount of 8-hydroxyhexadecanoic acid, or a salt thereof, thereby treating said cancer;
wherein said cancer is leukemia;
wherein said leukemia is mediated by CCRF-CEM, K-562, SR, MOLT-4, RPMI-8226, or HL-60(TB) cancer cells.