# US 10,478,461 B2 · Cellular extracts

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- Number: US 10,478,461 B2
- Document ID: US10478461B2
- Status: Granted
- Kind: B2
- Application number: 16/011,134
- Filed: 2018-06-18
- Published: 2018-10-25
- Granted: 2019-11-19
- Earliest claimed: 2006-05-11
- Assignees: Regenics AS
- Applicants: Regenics AS
- Inventors: Runhild Gammelsaeter; Jan Remmereit
- Web page: https://patentgrep.com/patent/US10478461B2

## CPC

- A61K 35/60: Fish, e.g. seahorses; Fish eggs
- A61K 8/987: {of species other than mammals or birds}
- A61K 9/06: Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)}
- A61K 35/65: Amphibians, e.g. toads, frogs, salamanders or newts
- A61P 17/00: Drugs for dermatological disorders
- A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like
- A61P 17/12: Keratolytics, e.g. wart or anti-corn preparations
- A61Q 19/00: Preparations for care of the skin
- A61Q 19/08: Anti-ageing preparations
- A61K 2800/805: Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

The invention describes methods and agents for improving cosmetic appearance, for promoting, improving or restoring health of cells and tissues, preferably skin, and more preferably, for restoring aged or damaged skin to a healthy appearance. The agents include compositions of cells, eggs, cell extracts, egg extracts, and extract components such as purified nucleic acids, polypeptides, lipids, carbohydrates or other natural products.

## Claims

### Claim 1

A method of improving wound healing in a human subject, comprising:
applying a composition comprising a trout egg cellular extract having a protein content of from about 210-270 mg/ml and an RNA content from about 3.51 to 4.68 mg/ml to a wound of said subject under conditions such wound healing is improved, wherein said improvement is selected from the group consisting of faster drying, faster reepithelialization, reduced inflammation, faster contraction, earlier remodeling, reduction in scar tissue and improved visual appearance of the wound and combinations thereof.

### Claim 2 (depends on 1)

The method of claim 1, wherein said composition is applied to a wound in the skin of said subject.

### Claim 3 (depends on 1)

The method of claim 1, wherein said composition is provided in a cream, gel, emulsion, ointment, spray, powder or lotion.

### Claim 4 (depends on 1)

The method of claim 1, wherein said trout egg extract is a cytoplasmic extract.

### Claim 5

A method of improving wound healing in a human subject, comprising:
applying a composition comprising a salmon egg cellular extract having a protein content of from about 180-260 mg/ml to a wound of said subject under conditions such wound healing is improved, wherein said improvement is selected from the group consisting of faster healing, increased scar tissue reorganization, less visible scar tissue thickness, lower epidermal thickness, lower dermal thickness and combinations thereof.

### Claim 6 (depends on 5)

The method of claim 5, wherein said composition is applied to a wound in the skin of said subject.

### Claim 7 (depends on 5)

The method of claim 5, wherein said composition is provided in a cream, gel, emulsion, ointment, spray, powder or lotion.

### Claim 8 (depends on 5)

The method of claim 5, wherein said salmon egg extract is a cytoplasmic extract.