# US 10,478,414 B2 · Neuroregeneration supplement

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- Number: US 10,478,414 B2
- Document ID: US10478414B2
- Status: Granted
- Kind: B2
- Application number: 15/944,860
- Filed: 2018-04-04
- Published: 2018-10-04
- Granted: 2019-11-19
- Earliest claimed: 2017-04-04
- Applicants: Alicia Marie Wiggins
- Inventors: Alicia Marie Wiggins
- Web page: https://patentgrep.com/patent/US10478414B2

## CPC

- A61K 31/198: Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00)
- A61K 31/191: having two or more hydroxy groups, e.g. gluconic acid
- A61K 31/675: having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A composition for enhancing neuroregeneration of the sciatic nerve in a mammal is provided that includes medicinally effective amounts of glycine, glutamine, and phenylalanine. In some embodiments, the glutamine can be L-glutamine and the phenylalanine can be D, L-phenylalanine. A method for treating sciatic pain is also included.

## Claims

### Claim 1

A composition for enhancing neuroregenation of peripheral nerves of a mammal consisting:
between about 40 and 48 percent of L-glycine;
between about 10 and 15 percent L-glutamine; and
between about 30 and 37 percent D, L-phenylalanine of the composition.

### Claim 2

A composition for enhancing neuroregenation of the sciatic nerves of a mammal, comprising:
between about 40 and 48 percent of L-glycine;
between about 10 and 15 percent L-glutamine; and
between about 30 and 37 percent D, L-phenylalanine of the composition,
wherein said composition provides effective relief for sciatic nerve pain without adverse effects.

### Claim 3 (depends on 2)

The composition of claim 2, further comprising Vitamin B6 or magnesium gluconate of combinations thereof.

### Claim 4 (depends on 2)

The composition of claim 2, further comprising between about 9 and 15 percent of magnesium gluconate or about 1 and 3 percent of Vitamin B6 or combination thereof.

### Claim 5

A method for providing relief for sciatic nerve injury consisting essentially of:
providing between about 40 and 48 percent_L-glycine;
providing between about 10 and 15 percent_L-glutamine; and
providing between about 30 and 37 percent D, L-phenylalanine in a composition suitable to enhance neuroregenation of sciatic nerves.

### Claim 6 (depends on 5)

The method of claim 5, wherein non-essential adjuvants are incorporated.

### Claim 7 (depends on 5)

The method of claim 5, wherein the non-essential adjuvants are selected from a group consisting essentially of Vitamin B6, magnesium gluconate, magnesium stearate, sodium ascorbate, ascorbic acid, calcium pantothenate, niacinamide, di-alpha tocopheryl acetate, microcrystalline cellulose, artificial colors and flavors, dextrin, starch, mono-and diglycerides, vitamin A acetate, gelatin, FD&C blue #1, FD&C red #3, artificial colors, thiamin mononitrate, pyridoxine, hydrochloride, citric acid, lactose, sorbic acid, tricalcium phosphate, sodium benzoate, sodium caseinate, methylparaben, potassium sorbate, BHA, BHT, ergocalciferol, cyanocobalamin or combinations thereof.