# US 10,478,393 B2 · Method of cosmetic treatment to protect the skin from pollution and improve skin regeneration

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 10,478,393 B2
- Document ID: US10478393B2
- Status: Granted
- Kind: B2
- Application number: 15/564,806
- Filed: 2016-03-30
- Published: 2018-04-19
- Granted: 2019-11-19
- Earliest claimed: 2015-04-09
- Assignees: ISP Investments Inc.; ELC Management LLC
- Applicants: ISP Investments LLC; ELC Management LLC
- Inventors: Frédérique Portolan; Jean-Marie Botto; Joel Mantelin; Isabelle Imbert; Nouha Domloge; Daniel B. Yarosh; Nevena Jurukovska-Karaman; Nadine A. Perdonet; Kelly Dong; Edward Pelle
- Web page: https://patentgrep.com/patent/US10478393B2

## CPC

- A61K 8/9794: Liliopsida [monocotyledons]
- A61K 8/9789: Magnoliopsida [dicotyledons]
- A61P 17/16: Emollients or protectives, e.g. against radiation
- A61P 17/18: Antioxidants, e.g. antiradicals (preparations for protection against sunlight A61Q17/00)
- A61P 39/06: Free radical scavengers or antioxidants
- A61Q 19/00: Preparations for care of the skin
- A61Q 19/08: Anti-ageing preparations
- A61K 2800/5922: At least two compounds being classified in the same subclass of A61K8/18
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

The present invention relates to the cosmetic use of a combination of a hydrolysed rice extract and a grapeseed extract as an active agent to protect cutaneous cells from pollution. The present invention relates also to a cosmetic method of treatment for protecting skin epidermal cells from atmospheric pollution comprising applying on the skin area to be treated a composition comprising a combination of a hydrolysed rice extract and a grapeseed extract.

## Claims

### Claim 1

A cosmetic treatment method for protecting skin epidermal cells from DNA damages induced by ozone exposure and UVB irradiation, comprising topically applying to skin in need thereof an effective amount of a cosmetic composition wherein the composition comprises 0.5 to 2% of an active ingredient consisting of a combination of a hydrolysed rice extract and a grapeseed extract in a ratio adjusted at 9:1 (w/w) and a physiologically acceptable medium, wherein the process to prepare the active ingredient comprises the following steps:
a. obtaining hydrolysed rice extract by enzymatic hydrolysis with vegetal enzymes, said hydrolysed rice extract is consisting of low molecular weight peptides of molecular weight less than 6 kDa,
b. purifying the hydrolysed rice extract using decreasing porosity filters;
c. obtaining the grapeseed extract from grapeseed cake in water at a pH between 4 and 7,
d. purifying the grapeseed extract using decreasing porosity filters; and
e. combining the extracts obtained at step b and d in a weight ratio of 9:1
f. adding 30% of glycerol in 70% of the product obtained at step e to prepare the active ingredient
g. using the active ingredient obtained at step f to prepare a cosmetic composition comprising the active ingredient at a weight ratio of 0.5 to 2% of the cosmetic composition.

### Claim 2 (depends on 1)

The cosmetic treatment method of claim 1, wherein the combination of a hydrolysed rice extract and a grapeseed extract comprises a protein content ranging between 10 and 20 g/Kg, and more preferably a protein content of 15 g/Kg.

### Claim 3 (depends on 1)

The cosmetic treatment method of claim 1, wherein the hydrolysed rice extract is consisting of peptides with a molecular weight of less than 6 kDa.

### Claim 4 (depends on 1)

The cosmetic treatment method of claim 1, wherein the method is used to improve skin regeneration and repair.

### Claim 5 (depends on 1)

The cosmetic treatment method of claim 1, wherein the method is used for preventing and/or treating the signs of skin aging and photo-aging due to pollution harmful effects.