# US 10,478,392 B2 · Peptide and cosmetic composition comprising same for preventing skin aging or skin wrinkle formation

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- Number: US 10,478,392 B2
- Document ID: US10478392B2
- Status: Granted
- Kind: B2
- Application number: 15/771,222
- Filed: 2016-10-27
- Published: 2018-11-15
- Granted: 2019-11-19
- Earliest claimed: 2015-10-27
- Assignees: College of Medicine Pochon Cha University Industry-Academic Cooperation Foundation
- Applicants: College of Medicine Pochon CHA University Industry-Academic Cooperation Foundation
- Inventors: Ji-Hyung Chung
- Web page: https://patentgrep.com/patent/US10478392B2

## CPC

- A61K 8/64: Proteins; Peptides; Derivatives or degradation products thereof
- A61Q 19/08: Anti-ageing preparations
- C07K 7/08: having 12 to 20 amino acids (gastrins C07K14/595; somatostatins C07K14/655; melanotropins C07K14/68)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)

## Abstract

Provided herein is a peptide, a cosmetic composition comprising the same, and a method for inhibiting skin-aging or skin-wrinkle formation using the same, the peptide having activities for facilitating the bindings between keratinocytes; and increasing the expressions of junction proteins.

## Claims

### Claim 1

A peptide having an activity of facilitating bindings between keratinocytes and increasing expression of junction proteins, consisting of the sequence of SEQ ID NO: 2.

### Claim 2

A method for reducing skin-aging or skin-wrinkle formation, comprising applying an effective amount of a peptide consisting of the sequence of SEQ ID NO: 2 to the skin of a subject in need thereof.

### Claim 3

A peptide comprising the sequence of SEQ ID NO: 1 or SEQ ID NO: 3.

### Claim 4

A cosmetic composition comprising a peptide comprising the sequence of SEQ ID NO: 1 or SEQ ID NO: 3.

### Claim 5

A method for reducing skin-aging or skin-wrinkle formation, comprising applying an effective amount of a peptide comprising the sequence of SEQ ID NO: 1 or SEQ ID NO: 3 to the skin of a subject in need thereof.