# US 10,478,391 B2 · Skin-care formulation for treating anti-aging and wrinkle reduction

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- Number: US 10,478,391 B2
- Document ID: US10478391B2
- Status: Granted
- Kind: B2
- Application number: 15/175,461
- Filed: 2016-06-07
- Published: 2016-12-08
- Granted: 2019-11-19
- Earliest claimed: 2015-06-08
- Applicants: Maryam Ershadi; Emanuel Itzhakian
- Inventors: Maryam Ershadi; Emanuel Itzhakian
- Web page: https://patentgrep.com/patent/US10478391B2

## CPC

- A61K 8/64: Proteins; Peptides; Derivatives or degradation products thereof
- A61K 8/19: containing inorganic ingredients
- A61K 8/345: {containing more than one hydroxy group}
- A61K 8/365: Hydroxycarboxylic acids; Ketocarboxylic acids
- A61K 8/44: Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K 8/4946: {Imidazoles or their condensed derivatives, e.g. benzimidazoles}
- A61K 8/498: {having 6-membered rings or their condensed derivatives, e.g. coumarin}
- A61K 8/73: Polysaccharides
- A61K 8/735: {Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof}
- A61K 8/97: from algae, fungi, lichens or plants; from derivatives thereof
- A61K 8/987: {of species other than mammals or birds}
- A61K 8/988: {Honey; Royal jelly, Propolis}
- A61Q 19/08: Anti-ageing preparations
- A61K 2800/59: Mixtures
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

The present disclosure relates to skincare products for treating the aging related issues of wrinkles or accidents such as scarring or burning and more specifically to specific formulations used to improve user outcomes in regards to skin elasticity, appearance and/or hydration. The contemplated products relate to formulations including combinations of biomimetic peptides and proteins of naturally occurring venoms in various known wildlife including bees, wasps, snakes, or snails, in a single formulation or in combination with various plant related ingredients with various carrier and/or medicament ability.

## Claims

### Claim 1

A formulation comprising:
apitoxin;
a combination of Glycerin, Aqua, Dipeptide Diaminobutyroyl Benzylamide Diacetate equivalent biomimetic peptide;
μconotoxin CnCIII;
a combination of Glycerin, Aqua, Terminalia Ferdinandiana Fruit Extract;
at least one chelating agent;
wherein the at least one chelating agent is Tetrasodium Glutamate Diacetate that has a percentage range of 0.01-1.00% within the formulation;
deionized water that has a percentage range of 5-80% within the formulation;
at least one type of emollient that has a percentage range of 0.50-7.00% within the formulation;
wherein the at least one type of emollient is selected from a list consisting of Caprylic/Capric Triglyceride, Isononyl Isononanoate, Squalane and Pataua Oil;
at least one type of emulsifier that has a percentage range of 1.00-10.00% within the formulation;
wherein the at least one type of emulsifier is Hydrogenated Lecithin, C12-16 Alcohols, Palmitic Acid or Cetyl Alcohol, Glyceryl Stearate, PEG-75 Stearate, Ceteth-20 , Steareth-2 or both:
at least one a type of humectant, at least one a type of neutralizer, at least one a type of non-ionic surfactant/emulsifier and at least one a type of preservative; and
at least one a type of rheology modifier and at least one a type of sensorial modifier or mattifying agent.

### Claim 2 (depends on 1)

The formulation of claim 1, wherein the apitoxin has a percentage range of 0.01-1.00% within the formulation, the combination of Glycerin, Aqua, Dipeptide Diaminobutyroyl Benzylamide Diacetate has a percentage range of 1.00-8.00% within the formulation and the μconotoxin CnCIII has a percentage range of 1.00-8.00% within the formulation.

### Claim 3 (depends on 1)

The formulation of claim 1, further comprises 1) a combination of Glycerin, Albizia Julibrissin Bark Extract, Darutoside, and 2) sH-Ogliopeptide-1.

### Claim 4 (depends on 3)

The formulation of claim 3, wherein the combination of Glycerin, Albizia Julibrissin Bark Extract, Darutoside has a percentage range of 1.00-10.00% within the formulation and the sH-Ogliopeptide-1 has an amount of 0.05-0.8mg per 100g within the formulation.

### Claim 5

A formulation comprising:
0. 01-1.00% of apitoxin;
1. 00-8.00% of a combination of Glycerin, Aqua, Dipeptide Diaminobutyroyl Benzylamide Diacetate;
1. 00-8.00% of μconotoxin CnCIII;
a combination of Glycerin, Albizia Julibrissin Bark Extract, Darutoside;
a combination of Glycerin, Aqua, Terminalia Ferdinandiana Fruit Extract;
sH-Ogliopeptide-1;
at least one type of emollient selected from a list consisting of Caprylic/Capric Triglyceride, Isononyl Isononanoate, Squalane and Pataua Oil; and
at least one type of emulsifier, at least one a type of humectant, at least one a type of neutralizer, at least one a type of non-ionic surfactant/emulsifier, at least one a type of preservative, at least one a type of rheology modifier and at least one a type of sensorial modifier or mattifying agent.

### Claim 6 (depends on 5)

The formulation of claim 5, wherein the combination of Glycerin, Albizia Julibrissin Bark Extract, Darutoside has a percentage range of 1.00-10.00% within the formulation, the combination of Glycerin, Aqua, Terminalia Ferdinandiana Fruit Extract has a percentage range of 0.01-6.00% within the formulation, and the sH-Ogliopeptide-1 has an amount of 0.05-0.8 mg per 100 g within the formulation.

### Claim 7

A formulation comprising:
0. 01-1.00% of apitoxin;
1. 00-8.00% of a combination of Glycerin, Aqua, Dipeptide Diaminobutyroyl Benzylamide Diacetate;
1. 00-8.00% of μconotoxin CnCIII;
1. 00-10.00% of a combination of Glycerin, Albizia Julibrissin Bark Extract, Darutoside;
0.01-6.00% of a combination of Glycerin, Aqua, Terminalia Ferdinandiana Fruit Extract;
0.05-0.8mg of sH-Ogliopeptide-1 per every 100 g of the formulation;
at least one type of emollient, at least one type of emulsifier, at least one a type of humectant, at least one a type of neutralizer, at least one a type of non-ionic surfactant/emulsifier, at least one a type of preservative, at least one a type of rheology modifier and at least one a type of sensorial modifier or mattifying agent; and
aloe vera, amino acids, antioxidants and vitamins.