# US 10,478,332 B2 · Magnetic operating microscopes and methods of treatment and diagnosis using the same > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,478,332 B2 - Document ID: US10478332B2 - Status: Granted - Kind: B2 - Application number: 14/766,735 - Filed: 2014-02-06 - Published: 2016-01-28 - Granted: 2019-11-19 - Earliest claimed: 2013-02-07 - Assignees: Emmetrope Ophthalmics LLC - Applicants: Emmetrope Ophthalmics LLC - Inventors: Jeffrey L. Goldberg; Roger A. Goldberg - Web page: https://patentgrep.com/patent/US10478332B2 ## CPC - A61F 9/0017: {implantable in, or in contact with, the eye, e.g. ocular inserts} - A61B 3/132: {in binocular arrangement} - A61B 5/05: Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves (measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24) - A61B 5/4839: {combined with drug delivery} - A61B 90/20: Surgical microscopes characterised by non-optical aspects - A61K 9/0048: {Eye, e.g. artificial tears} - A61K 35/30: Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue - A61K 49/08: characterised by the carrier - A61M 5/007: {for contrast media} - A61M 37/00: Other apparatus for introducing media into the body (for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30); Percutany, i.e. introducing medicines into the body by diffusion through the skin (salt baths A61H33/04) - A61N 2/002: {in combination with another treatment} - A61N 2/02: using magnetic fields produced by coils, including single turn loops or electromagnets (A61N2/12 takes precedence) - A61N 2/06: using magnetic fields produced by permanent magnets (A61N2/12 takes precedence) - A61F 9/00: Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand (caps with means for protecting the eyes A42B1/0181; visors for helmets A42B3/22; eye baths A61H35/02; sunglasses or goggles having the same features as spectacles G02C) - A61K 9/0009: {involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis} - A61K 9/0019: {Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00)} - A61M 2037/0007: {having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents} - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract In certain aspects, the present invention is directed to a device selected from (a) an operating microscope with an attached or attachable magnet and (b) a magnet that is configured for attachment to an operating microscope. In either case, the magnet is configured to allow a patient's tissue to be viewed through the operating microscope while at the same time permitting the creation of a magnetic field of sufficient magnitude and direction to move a magnetic therapeutic and/or diagnostic agent lying within the tissue to a preferred location in the tissue. ## Claims ### Claim 1 A device selected from an operating microscope with an attached magnet or an attachable magnet that is configured for attachment to the operating microscope, wherein the attached magnet, or the attachable magnet when attached to the operating microscope, is configured to allow a patient's tissue to be viewed through the operating microscope while at the same time permitting the creation of an intraocular magnetic field of sufficient magnitude and direction to move a magnetic therapeutic agent, a magnetic diagnostic agent, or both, that is positioned inside the tissue to a target location within the tissue. ### Claim 2 (depends on 1) The device of claim 1, wherein the magnetic field generated by the attached or attachable magnet ranges from 0.1 Tesla to 10.0 Tesla. ### Claim 3 (depends on 1) The device of claim 1, wherein the attached or attachable magnet is a rare earth magnet. ### Claim 4 (depends on 1) The device of claim 1, wherein the attached or attachable magnet is an electromagnet comprising a conductive coil and a source of electrical power in electrical communication with the conductive coil. ### Claim 5 (depends on 1) The device of claim 1, wherein the device is the operating microscope with the attached magnet and wherein a center the magnetic field of the attached magnet is centered with an optical axis of the microscope. ### Claim 6 (depends on 1) The device of claim 1, wherein the device is the operating microscope with the attached magnet and wherein the attached magnet is movable in a plane that is perpendicular to an optical axis of the microscope. ### Claim 7 (depends on 1) The device of claim 1, wherein the device is the operating microscope with the attached magnet and wherein the attached magnet is movable along an axis that is coincident with or parallel with an optical axis of the microscope. ### Claim 8 (depends on 1) The device of claim 1, wherein the device is the operating microscope with the attached magnet and wherein a peak centration of magnetic force induced by the attached magnet coincides with a center of the field of focus of the microscope. ### Claim 9 (depends on 1) The device of claim 1, wherein the attached or attachable magnet is in the shape of a ring. ### Claim 10 (depends on 1) The device of claim 1, wherein the tissue is eye tissue and wherein the attached magnet, or the attachable magnet when attached to the operating microscope, is configured to generate an intraocular magnetic field that is strongest at an apex of the cornea. ### Claim 11 (depends on 1) The device of claim 1, wherein the tissue is eye tissue and wherein the attached magnet, or the attachable magnet when attached to the operating microscope, is configured to generate an intraocular magnetic field that is strongest at a periphery of the cornea. ### Claim 12 (depends on 1) The device of claim 1, wherein the magnetic therapeutic agent, the magnetic diagnostic agent, or both, is a ferromagnetic magnetic therapeutic agent, a ferrimagnetic therapeutic agent, a ferromagnetic diagnostic agent, or a ferrimagnetic diagnostic agent. ### Claim 13 (depends on 1) The device of claim 1, wherein the operating microscope is a binocular microscope. ### Claim 14 (depends on 1) The device of claim 1, wherein the operating microscope is an ophthalmic microscope. ### Claim 15 (depends on 1) A kit comprising a device in accordance with claim 1 and a container of a magnetic diagnostic agent, a magnetic therapeutic agent, or both. ### Claim 16 (depends on 15) The kit of claim 15, further comprising an injection device comprising a needle and a syringe. ### Claim 17 (depends on 15) The kit of claim 15, wherein the magnetic therapeutic agent, the magnetic diagnostic agent, or both, is a ferromagnetic magnetic therapeutic agent, a ferrimagnetic therapeutic agent, a ferromagnetic diagnostic agent, or a ferrimagnetic diagnostic agent. ### Claim 18 (depends on 15) The kit of claim 15, wherein the tissue is eye tissue and wherein the magnetic therapeutic agent, the magnetic diagnostic agent, or both, is selected from one or more of magnetic stem cells, magnetic corneal endothelial cells, magnetic retinal pigment epithelial cells, magnetic antibodies, magnetic growth factors, or magnetic cytokines. ### Claim 19 (depends on 1) The device of claim 1, wherein the device is the operating microscope with the attached magnet. ### Claim 20 A method of treatment comprising introducing a magnetic therapeutic agent, a magnetic diagnostic agent, or both, into tissue of a patient and providing a magnetic field of sufficient magnitude and direction to move the magnetic therapeutic agent, the magnetic diagnostic agent, or both, to a target location within the tissue, while the tissue is simultaneously observable through an operating microscope and wherein the magnetic field is provided by a magnet that is attached to the operating microscope. ### Claim 21 (depends on 20) The method of claim 20, wherein the magnetic therapeutic agent, the magnetic diagnostic agent, or both, is injected into an anterior chamber of an eye and wherein the magnetic therapeutic agent, the magnetic diagnostic agent, or both, is directed to apex of the cornea. ### Claim 22 (depends on 20) The method of claim 20, wherein the magnetic therapeutic agent, the magnetic diagnostic agent, or both, is injected into an anterior chamber of the eye and wherein the magnetic therapeutic agent, the magnetic diagnostic agent, or both, is directed to the periphery of the cornea. ### Claim 23 (depends on 20) The method of claim 20, wherein the tissue is eye tissue and wherein the magnetic therapeutic agent, the magnetic diagnostic agent, or both, is selected from one or more of magnetic stem cells, magnetic corneal endothelial cells, magnetic retinal pigment epithelial cells, magnetic trabecular meshwork cells, magnetic antibodies, magnetic growth factors, and magnetic cytokines. ### Claim 24 (depends on 20) The method of claim 20, wherein the magnetic therapeutic agent, the magnetic diagnostic agent, or both, is selected from magnetic drugs and biological therapeutics.