# US 10,478,311 B2 · Medical devices including titanium surface treatment

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- Number: US 10,478,311 B2
- Document ID: US10478311B2
- Status: Granted
- Kind: B2
- Application number: 15/675,864
- Filed: 2017-08-14
- Published: 2019-02-14
- Granted: 2019-11-19
- Earliest claimed: 2017-08-14
- Assignees: Globus Medical, Inc.
- Applicants: Globus Medical, Inc.
- Inventors: Mark Miccio; Jason Zappacosta
- Web page: https://patentgrep.com/patent/US10478311B2

## CPC

- A61F 2/4455: {for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages (intervertebral discs A61F2/442)}
- A61F 2/0077: {Special surfaces of prostheses, e.g. for improving ingrowth (A61F2/30767 takes precedence)}
- A61F 2/30771: {applied in original prostheses, e.g. holes or grooves}
- A61L 27/50: Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials}
- A61L 27/56: Porous materials, {e.g. foams or sponges}
- A61L 31/14: Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials}
- A61L 31/146: {Porous materials, e.g. foams or sponges}
- A61F 2002/0081: {directly machined on the prosthetic surface, e.g. holes, grooves (A61F2/30771 takes precedence)}
- A61F 2002/30092: {using shape memory or superelastic materials, e.g. nitinol}
- A61F 2002/30538: {for adjusting angular orientation}
- A61F 2002/30593: {hollow}
- A61F 2002/30784: {Plurality of holes}
- A61F 2002/30836: {knurled}
- A61F 2002/30838: {Microstructures}
- A61F 2002/3092: {having an open-celled or open-pored structure}
- A61F 2002/30925: {etched}
- A61F 2002/3093: {for promoting ingrowth of bone tissue}
- A61F 2002/4629: {connected to the endoprosthesis or implant via a threaded connection}
- A61F 2310/00017: Iron- or Fe-based alloys, e.g. stainless steel
- A61F 2310/00023: Titanium or titanium-based alloys, e.g. Ti-Ni alloys
- A61F 2310/00029: Cobalt-based alloys, e.g. Co-Cr alloys or Vitallium
- A61F 2310/00059: Chromium or Cr-based alloys
- A61F 2310/00095: Niobium or Nb-based alloys
- A61L 2400/18: Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
- A61L 2430/02: for reconstruction of bones; weight-bearing implants
- A61L 2430/38: for reconstruction of the spine, vertebrae or intervertebral discs
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)

## Abstract

A surgical implant having a surface treatment which contains primary cavities and secondary cavities. The primary cavities are larger than the secondary cavities and the primary cavities have an average length ranging from 20-500 micrometers. The surface treatment includes recasted material adjacent to a plurality of the primary cavities.

## Claims

### Claim 1

A surgical implant comprising:
a body sized and configured to be inserted in a disc space, the body comprising an upper surface and a lower surface, wherein at least one of the upper surface and lower surface comprises a surface treatment which contains primary cavities and secondary cavities, the primary cavities being larger than the secondary cavities, wherein the primary cavities have an average length ranging from 20-500 micrometers, and wherein the surface treatment comprises recasted material adjacent to a plurality of the primary cavities.

### Claim 2 (depends on 1)

The surgical implant of claim 1, wherein one or more of the primary cavities is completely spherical.

### Claim 3 (depends on 1)

The surgical implant of claim 1, wherein one or more of the primary cavities is formed of two or more conjoined spherical portions.

### Claim 4 (depends on 1)

The surgical implant of claim 1, wherein the recasted material is adjacent to at least 80% of the primary cavities, and wherein the recasted material encircles the entire perimeters of at least 50% of the primary cavities.

### Claim 5 (depends on 1)

The surgical implant of claim 1, wherein the recasted material has an average height of 1-100 micrometers, the primary cavities have an average depth of 19-499 micrometers from a surface of the implant, and the secondary cavities have an average depth of 5 nanometers to 10 micrometers.

### Claim 6 (depends on 1)

The surgical implant of claim 1, wherein the implant comprises at least one selected from the group consisting of an implantable grade metal, metal alloy, or metal oxide.

### Claim 7 (depends on 1)

The surgical implant of claim 1, wherein at least some of the primary cavities are barbell shaped.

### Claim 8

A surgical implant comprising:
an implantable body formed at least in part of a metal sized and configured to be inserted in a disc space, the body comprising an upper surface and a lower surface, wherein at least one of the upper surface and the lower surface comprises a surface treatment which contains primary cavities and secondary cavities, the primary cavities being larger than the secondary cavities and the primary cavities having an average length ranging from 20-500 micrometers, and wherein the surface treatment comprises recasted material adjacent to a plurality of the primary cavities.

### Claim 9 (depends on 8)

The surgical implant of claim 8, wherein the surgical implant is a spinal implant selected from the group consisting of: an expandable spacer, a plate and spacer system, an implant with a screw system, an occipito-cervico-thoracid stabilization system, a cervico-thoracid stabilization system, and a plate system.

### Claim 10 (depends on 8)

The surgical implant of claim 8, wherein the implant is at least one selected from the group consisting of an expandable spacer and a plate and spacer system.

### Claim 11 (depends on 8)

The surgical implant of claim 8, wherein the implant comprises a spacer and/or a plate, and wherein the surface treatment is present on both the upper surface and the lower surface of the body.

### Claim 12

A surgical implant comprising:
an implantable body formed at least in part of a metal sized and configured to be inserted in a disc space, the body comprising an upper surface and a lower surface, wherein at least one of the upper surface and the lower surface comprises a surface treatment which contains primary cavities and secondary cavities, the primary cavities being larger than the secondary cavities, and wherein the surface treatment comprises recasted material adjacent to a plurality of the primary cavities.

### Claim 13 (depends on 12)

The surgical implant of claim 12, wherein the upper and lower surface comprise the surface treatment.

### Claim 14 (depends on 12)

The surgical implant of claim 12, wherein the implantable body is expandable.

### Claim 15 (depends on 12)

The surgical implant of claim 12, wherein at least some of the primary cavities are completely spherical.

### Claim 16 (depends on 15)

The surgical implant of claim 15, wherein at least some of the primary cavities are non-spherical.

### Claim 17 (depends on 16)

The surgical implant of claim 16, wherein at least some of the primary cavities comprise two or more conjoined spheres.

### Claim 18 (depends on 16)

The surgical implant of claim 16, wherein at least some of the primary cavities are barbell shaped with a bridge.

### Claim 19 (depends on 12)

The surgical implant of claim 12, wherein at least some of the secondary cavities are formed within at least one of the primary cavities.

### Claim 20 (depends on 12)

The surgical implant of claim 12, wherein at least some of the secondary cavities are formed between two or more of the primary cavities.