Heart valve prosthesis and methods of manufacture and use

A valve prosthesis comprising:

• a valve body comprising a plurality of leaflets affixed to a skirt, adjoining leaflets affixed together to form commissures;
• and
• a self-expanding frame comprising an inflow section having a first row of cells in a circumferentially repeating pattern defining an inflow edge of the frame, and an outflow section having a second row of cells in a circumferentially repeating pattern and including a plurality of eyelets;
• wherein the area of individual cells in the first row of cells is less than the area of individual cells in the second row of cells;
• wherein the frame has a contracted delivery configuration and an expanded deployed configuration, wherein, when the frame is in the expanded deployed configuration, the outflow section diameter is larger than the inflow section diameter;
• wherein the frame supports the valve body, wherein a portion of the skirt is folded over the inflow edge of the frame and affixed to the first row of cells and the commissures are sewn to the frame between the first and second rows of cells.