# US 10,478,133 B2 · Systems and methods for calibrating a nuclear medicine imaging system > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,478,133 B2 - Document ID: US10478133B2 - Status: Granted - Kind: B2 - Application number: 15/298,940 - Filed: 2016-10-20 - Published: 2018-04-26 - Granted: 2019-11-19 - Earliest claimed: 2016-10-20 - Assignees: General Electric Company - Applicants: General Electric Company - Inventors: Moshe Levy; Jean-Paul Bouhnik; Yariv Grobshtein; Gil Amisar; Yaron Hefetz - Web page: https://patentgrep.com/patent/US10478133B2 ## CPC - A61B 6/037: {Emission tomography} - A61B 6/06: Diaphragms - A61B 6/545: {involving automatic set-up of acquisition parameters} - A61B 6/585: {Calibration of detector units} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract Methods and systems are provided for calibrating a nuclear medicine imaging system. In one embodiment, a method comprises: detecting, with a plurality of detectors, photons emitted by a calibration source comprising a radioactive line source and a fluorescence source, while pivoting one or more detectors of the plurality of detectors; and calibrating, with a processor communicatively coupled to the plurality of detectors, each detector of the plurality of detectors based on energy measurements of the detected photons. In this way, a two-point energy calibration of detectors can be performed with a single isotope, and without removing or adjusting a collimator attached to the detector. ## Claims ### Claim 1 A method, comprising: detecting, with a plurality of detectors, photons emitted by a calibration source comprising a radioactive line source and a fluorescence source, while pivoting one or more detectors of the plurality of detectors; applying a geometrical correction to energy measurements of the detected photons, wherein applying the geometrical correction includes increasing photon counts of at least one pixel of the one or more detectors according to the pivoting of the one or more detectors; and calibrating, with a processor communicatively coupled to the plurality of detectors, each detector of the plurality of detectors based on the geometrically-corrected energy measurements of the detected photons. ### Claim 2 (depends on 1) The method of claim 1, further comprising applying the geometrical correction account for distortions in the photon counts and the energy measurements caused by the pivoting of the one or more detectors. ### Claim 3 (depends on 1) The method of claim 1, wherein applying the geometrical correction to the energy measurements comprises adjusting, for a pixel of the one or more detectors, photon counts recorded by the pixel based on a position of the pixel and the pivoting of the one or more detectors relative to the calibration source. ### Claim 4 (depends on 1) The method of claim 1, wherein calibrating each detector comprises adjusting a gain and an offset of each detector to account for differences between the energy measurements of the detected photons and a known energy spectrum of the calibration source. ### Claim 5 (depends on 1) The method of claim 1, wherein the plurality of detectors is coupled to a gantry, and further comprising, during the detecting of the photons, rotating the gantry. ### Claim 6 (depends on 1) The method of claim 1, wherein the radioactive line source comprises a cylinder filled with a single isotope. ### Claim 7 (depends on 6) The method of claim 6, wherein the fluorescence source comprises a sheath, and wherein the radioactive line source is positioned within the sheath. ### Claim 8 (depends on 7) The method of claim 7, wherein the sheath comprises one of a thin foil or a wire. ### Claim 9 (depends on 6) The method of claim 6, wherein the fluorescence source comprises a plurality of planar foils extending radially from the radioactive line source. ### Claim 10 (depends on 6) The method of claim 6, wherein the fluorescence source comprises a slab fixedly attached to the radioactive line source. ### Claim 11 A system, comprising: a gantry defining a bore; a calibration source comprising a radioactive line source and a fluorescence source, the calibration source positioned within the bore; a plurality of detectors coupled to the gantry and configured to detect radiation from the calibration source; and a processor communicatively coupled to the plurality of detectors and configured with instructions in non-transitory memory that, when executed, cause the processor to: detect, with the plurality of detectors, photons emitted by the calibration source while pivoting one or more detectors of the plurality of detectors; apply a geometrical correction to an energy spectrum of the detected photons by adjusting photon counts and energy measurements recorded by pixels of the one or more detectors according to the pivoting of the one or more detectors, wherein adjusting the photon counts and the energy measurements for a pixel includes increasing or decreasing the photon counts and the energy measurements according to a position of the pixel; and adjust a gain and an offset of at least one detector of the plurality of detectors based on the geometrically-corrected energy spectrum of the detected photons. ### Claim 12 (depends on 11) The system of claim 11, wherein the calibration source is anisotropic, and wherein the processor is further configured with instructions in the non-transitory memory that, when executed, cause the processor to rotate the gantry to reposition the plurality of detectors relative to the calibration source. ### Claim 13 (depends on 11) The system of claim 11, wherein the calibration source is isotropic. ### Claim 14 (depends on 11) The system of claim 11, wherein the radioactive line source comprises an isotope of cobalt and the fluorescence source comprises tungsten. ### Claim 15 (depends on 13) The system of claim 13, wherein the fluorescence source comprises a sheath that encloses the radioactive line source. ### Claim 16 (depends on 13) The system of claim 13, wherein the fluorescence source is integrally formed with the radioactive line source. ### Claim 17 A system, comprising: a detector of a nuclear medicine (NM) imaging system with a length along an axial direction of the NM imaging system; and a calibration source positioned within the NM imaging system for calibrating the detector, the calibration source comprising: a radioactive line source shaped as a cylinder with a length equal to or greater than the length of the detector of the NM imaging system, the radioactive line source comprising a radioisotope with an energy spectrum including a first energy peak; and a fluorescence source, wherein an energy spectrum of the fluorescence source includes a second energy peak, the second energy peak distinguishable from the first energy peak by the detector. ### Claim 18 (depends on 17) The system of claim 17, wherein the fluorescence source comprises a tungsten powder distributed throughout the radioactive line source. ### Claim 19 (depends on 17) The system of claim 17, wherein the fluorescence source comprises a tungsten foil or a tungsten wire forming a sheath around the radioactive line source. ### Claim 20 (depends on 17) The system of claim 17, wherein the fluorescence source comprises a tungsten slab, and the radioactive line source is fixedly attached to, and positioned in the center of, the tungsten slab.