# US 10,478,122 B2 · Measurement method and measurement device for brown adipose tissue > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,478,122 B2 - Document ID: US10478122B2 - Status: Granted - Kind: B2 - Application number: 14/917,581 - Filed: 2014-08-27 - Published: 2016-08-04 - Granted: 2019-11-19 - Earliest claimed: 2013-09-12 - Assignees: Tokyo Medical University; Hamamatsu Photonics K.K. - Applicants: Tokyo Medical University; Hamamatsu Photonics K.K. - Inventors: Takafumi Hamaoka; Shinsuke Nirengi; Masayuki Saito; Takeshi Yoneshiro - Web page: https://patentgrep.com/patent/US10478122B2 ## CPC - A61B 5/4872: {Body fat} - A61B 5/14546: {for measuring analytes not otherwise provided for, e.g. ions, cytochromes} - A61B 5/1455: using optical sensors, e.g. spectral photometrical oximeters - A61B 5/14551: {for measuring blood gases} - A61B 5/7275: {Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract A measurement method for brown adipose tissue includes a light input step of inputting near-infrared light from a light input unit into a measurement target portion, a light detection step of detecting light intensity of the near-infrared light having propagated through an interior of the measurement target portion by a light detection unit, and a calculation step of calculating an index value for a BAT amount from an oxygenated hemoglobin concentration or the like of the measurement target portion, which is acquired by near-infrared spectroscopy based on the detection result by the light detection unit. ## Claims ### Claim 1 A measurement method for brown adipose tissue, comprising: a light input step of inputting near-infrared light from a light input unit into a measurement target portion; a light detection step of detecting light intensity of the near-infrared light having propagated through an interior of the measurement target portion by a light detection unit; a calculation step of measuring any one value of an oxygenated hemoglobin concentration, a total hemoglobin concentration, and a first parameter of the measurement target portion, the first parameter increasing or decreasing depending upon the oxygenated hemoglobin concentration or the total hemoglobin concentration, which are acquired by near-infrared spectroscopy based on the detection result by the light detection unit; a defining step in which an index value for a brown adipose tissue amount is defined as the any one value measured; and a determination step of comparing the index value with a threshold value to determine whether the brown adipose tissue amount is negative or positive. ### Claim 2 (depends on 1) The measurement method for brown adipose tissue according to claim 1, wherein the any one value is corrected so as to reduce influence of a body fat amount using data indicating a correlation of a second parameter for the body fat amount with the any one value or with measurement sensitivity. ### Claim 3 A measurement method for brown adipose tissue, comprising: a light input step of inputting near-infrared light from a light input unit into a measurement target portion; a light detection step of detecting light intensity of the near-infrared light having propagated through an interior of the measurement target portion by a light detection unit; a calculation step of measuring any one value of a scattering coefficient and a deoxygenated hemoglobin concentration of the measurement target portion, which are acquired by near-infrared spectroscopy based on the detection result by the light detection unit; a defining step in which an index value for a brown adipose tissue amount is defined as the any one value measured; and a determination step of comparing the index value with a threshold value to determine whether the brown adipose tissue amount is negative or positive. ### Claim 4 A measurement apparatus for brown adipose tissue, comprising: a light input unit inputting near-infrared light into a measurement target portion; a light detection unit detecting light intensity of the near-infrared light having propagated through an interior of the measurement target portion; and a calculator configured to define an index value for a brown adipose tissue amount by any one value of an oxygenated hemoglobin concentration, a total hemoglobin concentration, and a first parameter of the measurement target portion, the first parameter increasing or decreasing depending upon the oxygenated hemoglobin concentration or the total hemoglobin concentration, which are acquired by near-infrared spectroscopy based on the detection result by the light detection unit, wherein the calculator is configured to compare the index value with a threshold value to determine whether the brown adipose tissue amount is negative or positive. ### Claim 5 (depends on 4) The measurement apparatus for brown adipose tissue according to claim 4, further comprising a storage unit storing data indicating a correlation of a second parameter for a body fat amount with the any one value or with measurement sensitivity, wherein the any one value is corrected so as to reduce influence of the body fat amount using the data. ### Claim 6 A measurement apparatus for brown adipose tissue, comprising: a light input unit inputting near-infrared light into a measurement target portion; a light detection unit detecting light intensity of the near-infrared light having propagated through an interior of the measurement target portion; and a calculator configured to define an index value for a brown adipose tissue amount by any one of a scattering coefficient and a deoxygenated hemoglobin concentration of the measurement target portion, which are acquired by near-infrared spectroscopy based on the detection result by the light detection unit, wherein the calculator is configured to compare the index value with a threshold value to determine whether the brown adipose tissue amount is negative or positive. ### Claim 7 (depends on 3) The measurement method for brown adipose tissue according to claim 3, further comprising a determination step of comparing the index value with a threshold value to determine whether the brown adipose tissue amount is negative or positive.