# US 10,478,119 B2 · System and method for drug dosage medicament regime adherence monitoring > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,478,119 B2 - Document ID: US10478119B2 - Status: Granted - Kind: B2 - Application number: 15/486,311 - Filed: 2017-04-13 - Published: 2018-09-27 - Granted: 2019-11-19 - Earliest claimed: 2017-03-24 - Applicants: Othman Abdulrahim Radi Alhanbali - Inventors: Othman Abdulrahim Radi Alhanbali - Web page: https://patentgrep.com/patent/US10478119B2 ## CPC - A61B 5/4833: {Assessment of subject's compliance to treatment} - A61B 5/7267: {involving training the classification device} - A61J 7/0481: {working on a schedule basis} - G16H 20/13: delivered from dispensers - A61B 5/0022: {Monitoring a patient using a global network, e.g. telephone networks, internet} - A61B 5/02055: {Simultaneously evaluating both cardiovascular condition and temperature} - A61B 5/021: Measuring pressure in heart or blood vessels - A61B 5/0816: {Measuring devices for examining respiratory frequency (measuring frequency of electric signals G01R23/00)} - A61B 5/14532: {for measuring glucose, e.g. by tissue impedance measurement} - A61B 5/14551: {for measuring blood gases} - A61J 7/0076: {Medicament distribution means (with pill counting devices A61J7/02; with time indication A61J7/04; containers or packages with special means for dispensing contents B65D83/00)} - A61J 2200/30: Compliance analysis for taking medication - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61J: CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE - G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA ## Abstract There is provided a method for oral drug dosage medicament regime adherence monitoring comprising creating an oral drug dosage medicament regime for a patient, the medicament regime having a plurality of medicament intervals for the oral consumption of a plurality of oral drugs, loading the plurality of oral drugs into a cartridge of an oral drug dispensing device, providing a patient wearable vital sign monitoring device for being worn by the patient and associating the patient wearable vital sign monitoring device and the oral drug dispensing device with a patient profile, the patient profile being further associated with the oral drug dosage medicament regime. Then, for at least one medicament interval, the method comprises: alerting the patient of the medicament interval using at least one of the patient wearable vital sign monitoring device and the oral drug dispensing device; obtaining first vital sign measurement data for the patient using the patient wearable vital sign monitoring device; detecting the dispensing of an oral drug from the cartridge of the of oral drug dispensing device; obtaining second vital sign measurement data for the patient post the dispensing using the patient wearable vital sign monitoring device, and comparing the first and second vital sign measurement data to calculate a probability of the oral consumption of the oral drug. ## Claims ### Claim 1 A method for oral drug dosage medicament regime adherence monitoring comprising: creating an oral drug dosage medicament regime for a patient, the medicament regime having a plurality of medicament intervals for the oral consumption of a plurality of oral drugs, loading the plurality of oral drugs into a cartridge of an oral drug dispensing device; providing a patient wearable vital sign monitoring device for being worn by the patient, associating the patient wearable vital sign monitoring device and the oral drug dispensing device with a patient profile, the patient profile being further associated with the oral drug dosage medicament regime, wherein, for at least one medicament interval, the method comprises: alerting the patient of the medicament interval using at least one of the patient wearable vital sign monitoring device and the oral drug dispensing device; obtaining first vital sign measurement data for the patient using the patient wearable vital sign monitoring device; detecting the dispensing of an oral drug from the cartridge of the of oral drug dispensing device; ascertaining the proximity of the patient wearable vital sign monitoring device and the oral drug dispensing device at substantially the same time as the detecting of the dispensing of the oral drug from the cartridge; obtaining second vital sign measurement data for the patient post the dispensing using the patient wearable vital sign monitoring device, and comparing the first and second vital sign measurement data to calculate a probability of the oral consumption of the oral drug. ### Claim 2 (depends on 1) A method as claimed in claim 1, wherein vital sign measurement data is indicative of at least one of heart rate, blood pressure, respiratory rate, body temperature, blood glucose levels and pulse oximetry measurements. ### Claim 3 (depends on 2) A method as claimed in claim 2, wherein the vital sign data represents more than one vital sign measurement. ### Claim 4 (depends on 3) A method as claimed in claim 3, wherein coordinating the probability comprises calculating the probability in accordance with the more than one vital sign measurements. ### Claim 5 (depends on 1) A method as claimed in claim 1, wherein the probability is a binary value. ### Claim 6 (depends on 5) A method as claimed in claim 5, wherein calculating the probability comprises utilising a deviation threshold. ### Claim 7 (depends on 1) A method as claimed in claim 1, wherein the probability is a scalar value. ### Claim 8 (depends on 7) A method as claimed in claim 7, wherein calculating the probability comprises utilising a probability distribution. ### Claim 9 (depends on 1) A method as claimed in claim 1, wherein the ascertaining of the proximity comprises establishing a short-range radio frequency communication channel between the patient wearable vital sign monitoring device and the oral drug dispensing device. ### Claim 10 (depends on 1) A method as claimed in claim 1, wherein the ascertaining of the proximity comprises obtaining location data obtained by both of the patient wearable vital sign monitoring device and the oral drug dispensing device and calculating a proximity distance utilising the location data. ### Claim 11 (depends on 1) A method as claimed in claim 1, wherein the ascertaining of the proximity comprises obtaining location data obtained by the patient wearable vital sign monitoring device and calculating a proximity distance utilising the location data and a known location of the oral drug dispensing device. ### Claim 12 (depends on 1) A method as claimed in claim 1, further comprising utilising a supervised machine learning technique to optimise parameters in accordance with historical vital sign response data and calculating the probability in accordance with the parameters. ### Claim 13 (depends on 12) A method as claimed in claim 12, wherein the parameters are further optimised in accordance with drug data. ### Claim 14 (depends on 12) A method as claimed in claim 12, wherein the parameters are further optimised in accordance with patient data. ### Claim 15 (depends on 12) A method as claimed in claim 12, wherein the parameters are artificial neural network weightings and wherein calculating the probability further comprises utilising an artificial neural network configured utilising the artificial neural network weightings. ### Claim 16 A method for oral drug dosage medicament regime adherence monitoring comprising: creating an oral drug dosage medicament regime for a patient, the medicament regime having a plurality of medicament intervals for the oral consumption of a plurality of oral drugs; loading the plurality of oral drugs into a cartridge of an oral drug dispensing device; providing a patient wearable vital sign monitoring device for being worn by the patient; associating the patient wearable vital sign monitoring device and the oral drug dispensing device with a patient profile, the patient profile being further associated with the oral drug dosage medicament regime, wherein, for at least one medicament interval, the method comprises: alerting the patient of the medicament interval using at least one of the patient wearable vital sign monitoring device and the oral drug dispensing device; obtaining first vital sign measurement data for the patient using the patient wearable vital sign monitoring device; detecting the dispensing of an oral drug from the cartridge of the of oral drug dispensing device; obtaining second vital sign measurement data for the patient post the dispensing using the patient wearable vital sign monitoring device; comparing the first and second vital sign measurement data to calculate a probability of the oral consumption of the oral drug; and utilising a supervised machine learning technique to optimise parameters in accordance with historical vital sign response data and calculating the probability in accordance with the parameters.