# US 10,478,101 B1 · Continuous glucose monitoring based on remote sensing of variations of parameters of a SiC implanted antenna > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,478,101 B1 - Document ID: US10478101B1 - Status: Granted - Kind: B1 - Application number: 15/286,173 - Filed: 2016-10-05 - Granted: 2019-11-19 - Earliest claimed: 2015-10-05 - Assignees: University of South Florida - Applicants: Fabiola Araujo Cespedes; Stephen E. Saddow; Christopher Leroy Frewin; Erdem Topsakal - Inventors: Fabiola Araujo Cespedes; Stephen E. Saddow; Christopher Leroy Frewin; Erdem Topsakal - Web page: https://patentgrep.com/patent/US10478101B1 ## CPC - A61B 5/14532: {for measuring glucose, e.g. by tissue impedance measurement} - A61B 5/0002: {Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network (endoradiosondes A61B5/07)} - A61B 5/14865: {invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors} - F23N 1/002: {using electronic means (F23N1/04 - F23N1/10 take precedence)} - F23N 1/005: {using electrical or electromechanical means (F23N1/04 - F23N1/10 take precedence)} - A61B 2560/0219: of externally powered implanted units - F23N 2223/38: Remote control - F23N 2225/16: burner temperature - F23N 2227/22: Pilot burners - F23N 2235/14: electromagnetically operated - F23N 2239/04: Gaseous fuels - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - F23N: REGULATING OR CONTROLLING COMBUSTION (control devices specially adapted for combustion apparatus in which combustion takes place in a fluidised bed of fuel or other particles F23C10/28; condition responsive controls for regulating combustion in domestic stoves with open fires for solid fuel F24B1/187) ## Abstract A passive sensing continuous glucose monitoring system and method of use thereof. The system includes a passive antenna formed of biocompatible silicon carbide (SiC), modeled to a desired frequency, which is permanently implanted subcutaneously. The system further includes an external-to-the-body transmitting antenna to detect changes in the blood glucose level by sending a radio signal at the frequency of the implanted passive antenna into the body. This signal is received and reflected by the passive antenna, and the reflected signal is then received at an external-to-the-body receiving antenna. Changes in the glucose level lead to modifications in the signal and can be used to determine the blood glucose level externally. ## Claims ### Claim 1 A passive sensing continuous glucose monitoring system for continuously monitoring a glucose level in a patient or subject, comprising: an external transmitting antenna that is configured to be positioned outside of a body of said patient or subject, said transmitting antenna transmitting a radiofrequency signal into said body of said patient or subject; a passive internal antenna formed of silicon carbide and including an amorphous silicon carbide insulation, said internal antenna configured to be positioned subdermally in said patient or subject, said internal antenna receiving said radiofrequency signal from said transmitting antenna and configured to reflect said radiofrequency signal out of said body of said patient or subject, wherein a resonant frequency of said internal antenna varies as said blood glucose level in said patient or subject changes; an external receiving antenna that is configured to be positioned outside of said body of said patient or subject, said receiving antenna receiving said reflected radiofrequency signal from said internal antenna, wherein said external transmitting antenna and said external receiving antenna are disposed in proximity to each other, and said passive internal antenna is mounted directly towards said external transmitting antenna and said external receiving antenna; one or more power sources for powering said external transmitting antenna and said external receiving antenna, wherein said received radiofrequency signal is translated into a measure of said glucose level of said patient or subject; a display for displaying said measure of said glucose level of said patient or subject. ### Claim 2 (depends on 1) A passive sensing continuous glucose monitoring system as in claim 1, wherein said transmitting antenna and said receiving antenna are disposed adjacent to each other. ### Claim 3 (depends on 1) A passive sensing continuous glucose monitoring system as in claim 1, wherein said transmitting antenna includes a microcontroller and a signal generator, wherein said microcontroller controls frequency and times of said signal generated by said signal generator, such that said microcontroller controls the frequency sweep transmitted by said transmitting antenna. ### Claim 4 (depends on 3) A passive sensing continuous glucose monitoring system as in claim 3, wherein said signal generator is a direct digital synthesis integrated circuit or a phase-locked loop with voltage control oscillator. ### Claim 5 (depends on 1) A passive sensing continuous glucose monitoring system as in claim 1, further comprising: said receiving antenna including a microcontroller and a converter that converts radiofrequency power to direct current power (RF-to-DC converter), said RF-to-DC converter receiving said reflected signal and converting said reflected signal to a digital value that is transmitted to said microcontroller, said microcontroller storing said digital value in a storage module, processing said digital value into said glucose level, and displaying said glucose level on said display. ### Claim 6 (depends on 1) A passive sensing continuous glucose monitoring system as in claim 1, further comprising a controller input to control subsystem options, including calibration, storage, history, and default value restore. ### Claim 7 (depends on 6) A passive sensing continuous glucose monitoring system as in claim 6, wherein said controller input includes a keyboard. ### Claim 8 (depends on 1) A passive sensing continuous glucose monitoring system as in claim 1, wherein said transmitting antenna includes a signal generator, said receiving antenna includes a converter that converts radiofrequency power to direct current power (RF-to-DC converter), both of said transmitting antenna and said receiving antenna are in communication with a microcontroller, and said microcontroller is coupled to said display. ### Claim 9 (depends on 1) A passive sensing continuous glucose monitoring system as in claim 1, wherein said system operates in the industrial, scientific, and medical (ISM) radio band. ### Claim 10 (depends on 1) A passive sensing continuous glucose monitoring system as in claim 1, wherein said passive internal antenna is configured to be positioned in a fat layer of said patient or subject near a blood vessel of said patient or subject. ### Claim 11 A method of continuously and passively sensing and monitoring a glucose level in a patient or subject, comprising the steps of: making an incision in said patient or subject; implanting a passive internal antenna subdermally into said patient or subject; positioning an external transmitting antenna across from said implanted antenna outside of a body of said patient or subject; positioning an external receiving antenna across from said implanted antenna outside of a body of said patient or subject, wherein said external receiving antenna is positioned in proximity to said external transmitting antenna; mounting said passive internal antenna directly towards said external transmitting antenna and said external receiving antenna; said external transmitting antenna generating and transmitting a radiofrequency signal into said body of said patient or subject; said implanted antenna receiving said radiofrequency signal from said transmitting antenna and reflecting said radiofrequency signal out of said body of said patient or subject, wherein said passive internal antenna is formed of silicon carbide and includes amorphous silicon carbide insulation; said external receiving antenna receiving said reflected radiofrequency signal from said implanted antenna and processing said received radiofrequency signal into a measure of said glucose level of said patient or subject; displaying said glucose level of said patient or subject on a display, wherein a resonant frequency of said internal antenna varies as said blood glucose level in said patient or subject changes. ### Claim 12 (depends on 11) A method as in claim 11, wherein said transmitting antenna includes a signal generator, said receiving antenna includes a converter that converts radiofrequency power to direct current power (RF-to-DC converter), both of said transmitting antenna and said receiving antenna are in communication with a microcontroller, and said microcontroller is coupled to said display. ### Claim 13 (depends on 11) A method as in claim 11, wherein said system operates in the industrial, scientific, and medical (ISM) radio band. ### Claim 14 (depends on 11) A method as in claim 11, wherein the step of implanting said passive internal antenna subdermally into said patient or subject is performed by positioning said passive internal antenna in a fat layer of said patient or subject near a blood vessel of said patient or subject. ### Claim 15 A passive sensing continuous glucose monitoring system for continuously monitoring a glucose level in a patient or subject, comprising: an external transmitting antenna that is positioned outside of a body of said patient or subject, said transmitting antenna transmitting a radiofrequency signal into said body of said patient or subject; a passive internal antenna that is configured to be positioned subdermally in a fat layer of said patient or subject near a blood vessel of said patient or subject, said internal antenna receiving said radiofrequency signal from said transmitting antenna and reflecting said radiofrequency signal out of said body of said patient or subject, wherein a resonant frequency of said internal antenna varies as said blood glucose level in said patient or subject changes, wherein said passive internal antenna is formed of silicon carbide and further includes amorphous silicon carbide insulation, an external receiving antenna that is positioned outside of said body of said patient or subject, said receiving antenna receiving said reflected radiofrequency signal from said internal antenna, wherein said external transmitting antenna and said external receiving antenna are disposed adjacent to each other, and said passive internal antenna is mounted directly towards said external transmitting antenna and said external receiving antenna, one or more power sources for powering said external transmitting antenna and said external receiving antenna, wherein said received radiofrequency signal is translated into a measure of said glucose level of said patient or subject, a display for displaying said measure of said glucose level of said patient or subject, said transmitting antenna including a signal generator being a direct digital synthesis integrated circuit, said receiving antenna including a converter that converts radiofrequency power to direct current power (RF-to-DC converter), both of said transmitting antenna and said receiving antenna being in communication with a microcontroller, said microcontroller controlling frequency and times of said signal generated by said signal generator, such that said microcontroller controls the frequency sweep transmitted by said transmitting antenna, said RF-to-DC converter receiving said reflected signal and converting said reflected signal to a digital value that is transmitted to said microcontroller, said microcontroller storing said digital value in a storage module, processing said digital value into said glucose level, and displaying said glucose level on said display to which said microcontroller is coupled; a controller input to control subsystem options, including calibration, storage, history, and default value restore, wherein said controller input includes a keyboard, wherein said system operates in the industrial, scientific, and medical (ISM) radio band.