# US 10,478,073 B2 · Medical image processing apparatus > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,478,073 B2 - Document ID: US10478073B2 - Status: Granted - Kind: B2 - Application number: 14/725,893 - Filed: 2015-05-29 - Published: 2015-09-17 - Granted: 2019-11-19 - Earliest claimed: 2012-11-30 - Assignees: Canon Medical Systems Corporation - Applicants: Toshiba Medical Systems Corporation - Inventors: Hideaki Ishii; Satoshi Wakai; Kazumasa Arakita; Takuma Igarashi; Yasuko Fujisawa; Shigeo Kaminaga; Kenji Hirohata; Junichiro Ooga - Web page: https://patentgrep.com/patent/US10478073B2 ## CPC - A61B 5/02007: {Evaluating blood vessel condition, e.g. elasticity, compliance} - A61B 6/032: {Transmission computed tomography [CT]} - A61B 6/486: {involving generating temporal series of image data} - A61B 6/503: {for diagnosis of the heart} - A61B 6/504: {for diagnosis of blood vessels, e.g. by angiography} - A61B 6/5217: {extracting a diagnostic or physiological parameter from medical diagnostic data} - G06T 7/13: Edge detection - G16H 50/30: for calculating health indices; for individual health risk assessment - A61B 5/02028: {Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction} - A61B 5/026: Measuring blood flow {(A61B3/1233, A61B3/1241 take precedence)} - A61B 2576/023: for the heart - G06T 2207/10081: Computed x-ray tomography [CT] - G06T 2207/30101: Blood vessel; Artery; Vein; Vascular - G06T 2207/30172: Centreline of tubular or elongated structure - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - G06T: IMAGE DATA PROCESSING OR GENERATION, IN GENERAL - G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA ## Abstract A centerline extraction unit extracts at least two coronary artery centerline structures from at least two images respectively corresponding to at least two cardiac phases concerning a heart, an interpolation processing unit interpolates coronary artery centerline structures concerning other cardiac phases from the at least two extracted coronary artery centerline structures to generate coronary artery centerline structures respectively corresponding to a plurality of cardiac phases throughout one heartbeat of the heart, and a displacement distribution calculation unit calculates a plurality of displacement distributions between the respective cardiac phases from a plurality of coronary artery centerline structures throughout the one heartbeat. ## Claims ### Claim 1 A medical image processing apparatus comprising: circuitry configured to set a plurality of capture timings in one heartbeat of a heart based on cardiac phases, wherein a long time interval is set for a period in which movement of the heart is fast, and a short time interval is selected for a period in which movement of the heart is slow, capture plurality of volume data at the plurality of capture timings, extract at least two coronary artery centerline structures from the volume data, generate a plurality of coronary artery centerline structures concerning other cardiac phases between the at least two specific cardiac phases in the one heartbeat by interpolating the plurality of coronary artery centerline structures based on the at least two extracted coronary artery centerline structures, and calculate a plurality of displacement distributions representing a displacement at each point on the coronary artery centerline structure between respective cardiac phases of the plurality of cardiac phases, based on the plurality of coronary artery centerline structures at the phases in the one heartbeat. ### Claim 2 (depends on 1) The medical image processing apparatus according to claim 1, wherein the coronary artery centerline structures concerning the other cardiac phases are interpolated from a coronary artery centerline structure extracted from an image in an end systole phase of the heart and a coronary artery centerline structure extracted from an image in an end diastole phase. ### Claim 3 (depends on 1) The medical image processing apparatus according to claim 1, wherein the coronary artery centerline structures concerning the other cardiac phases are interpolated from a coronary artery centerline structure extracted from an image in an end systole phase of the heart, a coronary artery centerline structure extracted from an image in an end diastole phase, and a coronary artery centerline structure extracted from an image in a middle cardiac phase between the end systole and the end diastole. ### Claim 4 (depends on 1) The medical image processing apparatus according to claim 1, wherein time intervals between adjacent images of the plurality of images are irregular. ### Claim 5 (depends on 1) The medical image processing apparatus according to claim 1, wherein the volume data concerns a region including the heart. ### Claim 6 A medical image processing apparatus, comprising: circuitry configured to set a plurality of capture timings in one heartbeat of a heart based on cardiac phases, wherein a long time interval is set for a period in which movement of the heart is fast, and a short time interval is selected for a period in which movement of the heart is slow, capture plurality of volume data at the plurality of capture timings, extract at least two coronary artery centerline structures from the volume data, generate a plurality of coronary artery centerline structures concerning other cardiac phases between the at least two specific cardiac phases in one heartbeat of the heart by interpolating the plurality of coronary artery centerline structures based on the at least two extracted coronary artery centerline structures, calculate a plurality of displacement distributions representing a displacement at each point on the coronary artery centerline structure between respective cardiac phases of the plurality of cardiac phases, based on the plurality of coronary artery centerline structures at the phases in the one heartbeat, generate a three-dimensional coronary artery reference model from the volume data corresponding to at least one of the two cardiac phases, generate a plurality of three-dimensional coronary artery models for the phases in the one heartbeat by deforming the three-dimensional coronary artery reference model based on the plurality of displacement distributions, and calculate hardness of a blood vessel wall and blood inflow rate of a coronary artery corresponding to each of the plurality of cardiac phases in one heartbeat of the heart from a temporal change in the plurality of three-dimensional coronary artery models. ### Claim 7 (depends on 6) The medical image processing apparatus according to claim 6, wherein the three-dimensional coronary artery reference model is generated from volume data concerning a cardiac phase in an end diastole. ### Claim 8 (depends on 6) The medical image processing apparatus according to claim 6, further comprising a display configured to display the three-dimensional coronary artery model in a cardiac phase in the one heartbeat. ### Claim 9 (depends on 6) The medical image processing apparatus according to claim 6, wherein the plurality of three-dimensional generated coronary artery models constitute time-series data to form a four-dimensional coronary artery deformation model. ### Claim 10 (depends on 6) The medical image processing apparatus according to claim 6, wherein the coronary artery centerline structures concerning the other cardiac phases are interpolated from a coronary artery centerline structure extracted from an image in an end systole phase of the heart and a coronary artery centerline structure extracted from an image in an end diastole phase. ### Claim 11 (depends on 6) The medical image processing apparatus according to claim 6, wherein the coronary artery centerline structures concerning the other cardiac phases are interpolated from a coronary artery centerline structure extracted from an image in an end systole phase of the heart, a coronary artery centerline structure extracted from an image in an end diastole phase, and a coronary artery centerline structure extracted from an image in a middle cardiac phase between the end systole and the end diastole. ### Claim 12 (depends on 6) The medical image processing apparatus according to claim 6, wherein time intervals between adjacent images of the plurality of images are irregular. ### Claim 13 (depends on 6) The medical image processing apparatus according to claim 6, wherein the volume data concerns a region including the heart. ### Claim 14 (depends on 6) The medical image processing apparatus according to claim 6, wherein the circuitry is configured to generate a plurality of pressure distributions respectively corresponding to the plurality of cardiac phases from the calculated hardnesses of the blood vessel wall and the calculated blood inflow rates. ### Claim 15 (depends on 14) The medical image processing apparatus according to claim 14, wherein the circuitry is configured to generate a plurality of color maps with different hues corresponding to pressures from the plurality of pressure distributions. ### Claim 16 (depends on 15) The medical image processing apparatus according to claim 15, further comprising a display configured to superimpose and display the color map on the three-dimensional coronary artery model.