# US 10,477,860 B2 · High osmolarity antimicrobial composition containing one or more organic solvents > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,477,860 B2 - Document ID: US10477860B2 - Status: Granted - Kind: B2 - Application number: 15/976,806 - Filed: 2018-05-10 - Published: 2018-09-13 - Granted: 2019-11-19 - Earliest claimed: 2013-05-02 - Assignees: Next Science IP Holdings Pty Ltd - Applicants: Next Science IP Holdings Pty Ltd - Inventors: Matthew Franco Myntti - Web page: https://patentgrep.com/patent/US10477860B2 ## CPC - A01N 25/02: containing liquids as carriers, diluents or solvents - A01N 31/02: Acyclic compounds - A01N 33/12: Quaternary ammonium compounds - A01N 37/02: Saturated carboxylic acids or thio analogues thereof; Derivatives thereof - A01N 37/40: having at least one carboxylic group or a thio analogue, or a derivative thereof, and one oxygen or sulfur atom attached to the same aromatic ring system - A01N 41/10: Sulfones; Sulfoxides - A61K 8/33: containing oxygen - A61K 8/34: Alcohols - A61K 8/39: Derivatives containing from 2 to 10 oxyalkylene groups - A61K 8/416: {Quaternary ammonium compounds (A61K8/35 takes precedence)} - A61K 8/463: {containing sulfuric acid derivatives, e.g. sodium lauryl sulfate} - A61Q 17/005: {Antimicrobial preparations} - A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS ## Abstract A composition that can solvate biofilms and disrupt bacterial cell walls acts to both kill the bacteria by cell lysis and remove the biofilm. This solvent-containing composition is effective against a broad spectrum of microbes and can be used on a variety of surfaces, both living and inanimate. The polarity of the solvent component of the composition is lower than that of pure water so that the composition exhibits increased efficacy in solvating the macromolecular matrix of a biofilm and in penetrating bacterial cell walls. ## Claims ### Claim 1 An antimicrobial composition adapted for dermal application, said composition comprising (a) a carrier base and (b) a liquid composition exhibiting an effective solute concentration of at least about 0.75 Osm/L and a pH of at least 3, wherein said liquid composition consists of (1) a solvent component that exhibits a δp value of no more than 14.4 MPa1/2 and consists of water, one or more C1-C16 acyclic alcohols and, optionally, glycerol; and (2) a solute component that comprises cationic surfactant and dissociation products of at least two organic acids. ### Claim 2 (depends on 1) The antimicrobial composition of claim 1 wherein said liquid composition exhibits a pH of from 3.5 to 5.5. ### Claim 3 (depends on 1) The antimicrobial composition of claim 1 wherein said one or more C1-C16 acyclic alcohols comprises 2-propanol. ### Claim 4 (depends on 1) The antimicrobial composition of claim 1 wherein said at least two organic acids comprise one or more monoprotic acids. ### Claim 5 (depends on 4) The antimicrobial composition of claim 4 wherein said at least two organic acids further comprise one or more polyacids. ### Claim 6 (depends on 5) The antimicrobial composition of claim 5 wherein said solute component further comprises dissociation product of a salt of said one or more polyacids. ### Claim 7 (depends on 4) The antimicrobial composition of claim 4 wherein said one or more monoprotic acids comprises or is salicylic acid. ### Claim 8 (depends on 7) The antimicrobial composition of claim 7 wherein said at least two organic acids further comprise one or more polyacids. ### Claim 9 (depends on 8) The antimicrobial composition of claim 8 wherein said one or more polyacids comprises or is citric acid. ### Claim 10 (depends on 9) The antimicrobial composition of claim 9 wherein said solute component further comprises dissociation product of a salt of citric acid. ### Claim 11 (depends on 8) The antimicrobial composition of claim 8 wherein said solute component further comprises dissociation product of a salt of said one or more polyacids. ### Claim 12 (depends on 1) The antimicrobial composition of claim 1 wherein said cationic surfactant is benzalkonium chloride. ### Claim 13 (depends on 12) The antimicrobial composition of claim 12 wherein said benzalkonium chloride is present at up to 0.13 weight percent based on said liquid composition. ### Claim 14 (depends on 1) The antimicrobial composition of claim 1 comprising an oleaginous or absorption carrier base. ### Claim 15 (depends on 1) The antimicrobial composition of claim 1 comprising an emulsion carrier base. ### Claim 16 A composition adapted for dermal application, said composition comprising: a) a carrier base and b) a liquid composition which exhibits an effective solute concentration of at least about 0.65 Osm/L and a pH of from 3.5 to 5.5, wherein said liquid composition consists of 1) a solvent component that exhibits a δp value of no more than 14.4 MPa1/2 and consists essentially of water, 2-propanol and, optionally, glycerol; and 2) a solute component that comprises benzalkonium chloride, dissociation products of at least one monoprotic acid and at least one polyacid, and dissociation product of a salt of one of said at least one polyacid. ### Claim 17 (depends on 16) The composition of claim 16 wherein said at least one monoprotic acid comprises or is salicylic acid. ### Claim 18 (depends on 17) The composition of claim 17 wherein said at least one polyacid is citric acid. ### Claim 19 (depends on 16) The composition of claim 16 comprising an oleaginous or absorption carrier base. ### Claim 20 (depends on 16) The composition of claim 16 comprising an emulsion carrier base.