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US 10,477,097 B2Granted
Single-frame autofocusing using multi-LED illumination
AssigneeUniversity of Connecticut
InventorGuoan Zheng
Life of this patent
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AssigneeUniversity of Connecticut
InventorGuoan Zheng
Estimating the term…
Instruments, assemblies and methods are provided for undertaking imaging techniques (e.g., microscopic imaging techniques). The present disclosure provides improved imaging techniques, equipment and systems. More particularly, the present disclosure provides advantageous microscopy/imaging assemblies with single-frame sample autofocusing using multi-LED illumination. The present disclosure provides for assemblies and methods for single-frame rapid sample autofocusing without a z-scan. Potential applications for the disclosed assemblies/methods include, without limitation, whole slide imaging, optical metrology, wafer inspection, DNA sequencing and other high-throughput imaging applications where the sample may need to be scanned over a large field of view. The assemblies/methods advantageously utilize multiple LEDs for sample illumination. A captured image includes multiple copies of the sample, and one can recover the distance between these copies. The distance is directly related to the defocus distance.
An imaging assembly comprising:
An imaging method comprising:
An imaging method, comprising:
An imaging method, comprising:
Dependencies are inferred from the claim text.