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US 10,473,668 B2Granted
Self-shielded, benchtop radio chemistry system with a plurality shielded carriers containing a disposable chip cassette
AssigneesThe Regents of the University of California, Sofie Biosciences, Inc.
InventorsR. Michael Van Dam, Melissa Moore, Brandon Maraglia, Daniel Thompson
Life of this patent
Estimating the term…
Abstract
A self-shielded, bench-top radiochemistry system, including a radioactive isotope dispensing module configured to draw an isotope out of a vial and dispense one or more metered doses of the isotope to a concentration module that concentrates the metered dose into a droplet amount of isotope and a synthesizer module that delivers the droplet amount of isotope along with one or more reagents to an electrowetting on dielectrics (EWOD) chip to produce a radiolabeled molecule.
Claims19
A self-shielded, bench-top radio chemistry system for use without the need of a hot cell, comprising:
- a radioactive isotope dispensing module comprising fluid line, mechanical pump, and radiation sensor, the dispensing module configured to draw an isotope out of a reservoir and dispense a metered dose of said isotope;
- a concentration module comprising a solid-phase extraction cartridge and configured to receive the metered dose from the dispensing module and concentrate the metered dose into a droplet amount of isotope;
- a synthesizer module comprising a disposable chip cassette holding a microfluidic chip and a reagent cartridge configured to receive the droplet amount of isotope from the concentration module and deliver the droplet amount of isotope along with one or more reagents to the microfluidic chip to produce a radiolabeled molecule;
- a computer control system operably coupled to the radioactive isotope dispensing module, concentration module, and synthesizer module to automatically control their respective operations;
- a plurality of shielded carriers configured to hold the disposable chip cassette therein and openable to remove the disposable chip cassette therefrom;
- wherein each of the dispensing module, concentration module and synthesizer module are connected in fluid communication via one or more wetted paths;
- wherein the one or more wetted paths are exposed to said isotope;
- and
- wherein the microfluidic chip and portions of the one or more of the dispensing module, concentration module and synthesizer module corresponding to said one or more wetted paths are disposed in the disposable chip cassette contained in one of the plurality of shielded carriers disposed inside the bench-top radio chemistry system, wherein the shielded carrier containing the disposable chip cassette is removable from the bench-top radio chemistry system.
6 more elements
A method for generating a radiolabled molecule without the need of a hot cell, comprising:
- providing a self-shielded, bench-top radio chemistry system having a computer controlled radioactive isotope dispensing module, a concentration module, and a synthesizer module comprising a disposable chip cassette holding a microfluidic chip and a reagent cartridge, wherein the isotope is dispensed, concentrated and delivered to the microfluidic chip within one or more wetted paths of the radioactive isotope dispensing module, the concentration module, and the synthesizer module that are exposed to said isotope, and wherein the microfluidic chip and portions of the one or more wetted paths are disposed in the disposable chip cassette contained in a first shielded carrier;
- automatically drawing a radioactive isotope out of a reservoir contained in the radioactive isotope dispensing module with a mechanical pump and dispensing a metered dose of said isotope;
- automatically receiving the metered dose in the concentration module comprising a solid-phase extraction cartridge and concentrating the metered dose into a droplet amount of isotope;
- automatically delivering the droplet amount of isotope along with one or more reagents from the reagent cartridge to the microfluidic chip in the disposable chip cassette to produce a radiolabeled molecule;
- removing the first shielded carrier containing the disposable chip cassette from the bench-top radio chemistry system;
- loading a second shielded carrier containing a second disposable chip cassette into the bench-top radio chemistry system.
3 more elements
A self-shielded, bench-top radio chemistry system for use without the need of a hot cell, comprising:
- a radioactive isotope dispensing module comprising fluid line and a mechanical pump, the dispensing module configured to draw an isotope out of a reservoir and dispense a metered dose of said isotope;
- a plurality of shielded carriers;
- a disposable chip cassette holding a microfluidic chip and a reagent cartridge disposed in one of the plurality of shielded carriers, the chip cassette comprising a concentration module configured to receive the metered dose from the dispensing module and concentrate the metered dose into a droplet amount of isotope and a synthesizer module configured to receive the droplet amount of isotope from the concentration module and deliver the droplet amount of isotope along with one or more reagents to the microfluidic chip to produce a radiolabeled molecule;
- and
- a computer control system operably coupled to the radioactive isotope dispensing module, concentration module, and synthesizer module to automatically control their respective operations, wherein the shielded carrier containing the disposable chip cassette is removeable and replaceable with another shielded carrier containing another disposable chip cassette.
2 more elements
Dependencies are inferred from the claim text.