US 10,473,582 B2Granted

Combination optical hemoglobin and electrochemical lead assay

AssigneeMagellan Diagnostics, Inc.

InventorsNorman F. Sheppard, Jr., Gary Conrad Jensen

Life of this patent

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Abstract

A sensor and analyzer for measuring an analyte in a liquid sample are disclosed. The sensor includes a substrate with a reservoir disposed therein. The reservoir may include a top surface and a bottom surface, at least one transparent portion forming at least a part of the bottom surface of the reservoir, and a reflector disposed on the upper surface of the reservoir at a location opposite the at least one transparent portion. The analyzer may include a support surface, an aperture extending through the support surface, a light source disposed below the support surface and oriented so that at least a portion of the light emitted from the light source passes through the aperture, and a detector configured to measure an intensity of light received at the detector.

Claims7

Dependent claims

A method for measuring an analyte in a liquid sample, the method comprising:

flowing a liquid sample into a reservoir of a sensor, the reservoir comprising a first portion comprising a first depth and a second portion comprising a second depth that is greater than the first depth, wherein the reservoir is bounded by a first side and a second side such that the liquid sample within the reservoir is positioned between the first side and the second side;
determining a measurement of the analyte in the liquid sample by:
illuminating the liquid sample in the first portion of the reservoir through a transparent portion of the sensor, wherein the transparent portion of the sensor is on the first side of the first portion of the reservoir;
determining a reflectance of the liquid sample based on a measurement of light reflected off a reflector positioned on the second side of the first portion of the reservoir, wherein light for illuminating the sample passes through the transparent portion on the first side of the reservoir, through the liquid sample in the reservoir, and is reflected off the reflector on the second side of the reservoir;
and
determining the measurement of the analyte based on the determined reflectance.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application: 15/701,006Filed 11 Sep 2017 · continuation
Priority: 23 Dec 2014
Published: US 2018/0059010 A11 Mar 2018
Granted: 12 Nov 2019
Term ends: Not estimatedThe source records don’t support an estimate.

Classification7 codes

G01N 21/31
Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands:…
G01N 21/474
Diffuse reflection , e.g. also for testing fluids, fibrous materials: details of optical heads therefor, e.g. using optical fibres
G01N 33/49
Of liquid biological material: blood
G01N 2201/062
Illumination; Optics: led's

Family

Application62/096,178Us provisional application · filed 23 Dec 2014
Application14/978,292Parent of this continuation · filed 22 Dec 2015
US 2018/0059010 A1Pre-grant publication · published 1 Mar 2018
US 9,759,651 B2Parent of this continuation
US 2016/0178573 A1Published application
US 10,473,582 B2This patent

From the US filing history. Foreign family members aren’t listed.