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US 10,473,574 B2Granted
Assembly for assessing drug permeability with adjustable biomimetic properties
AssigneeSyddansk Universitet
InventorsMassimiliano Pio Di Cagno, Annette Bauer-Brandl
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Abstract
There is provided an assembly and process for its preparation for predicting the permeability of chemical compounds, comprising a donor compartment for adding a composition comprising the compound; a barrier based on a support and a phospholipid layer adhering to the support; and an acceptor compartment for accepting the compound upon permeation of the barrier.
Claims20
A barrier assembly, for determining permeability of one or more chemical compounds across a biological barrier, the barrier assembly comprising:
- a donor compartment for adding the chemical compound or a composition comprising the compound;
- an acceptor compartment for accepting the compound upon permeation across a barrier;
- and
- a barrier separating the donor compartment and acceptor compartment;
- wherein said barrier comprises on one side a polymeric support, a phospholipid layer adhering to the surface of the polymeric support, and a cover layer on top of the phospholipid layer.
2 more elements
Dependencies are inferred from the claim text.