Back to results
US 10,472,688 B2Granted
Compositions and methods for producing podophyllotoxin derivatives
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsWarren Lau, Elizabeth Sattely
Life of this patent
Estimating the term…
Abstract
The present invention provides compositions and methods for biosynthetically producing podophyllotoxin intermediates and derivatives including enzymes and their equivalents involved in the biosynthetic production of podophyllotoxin intermediates and derivatives.
Claims19
A genetically engineered host cell for use in biosynthesis of a podophyllotoxin intermediate or podophyllotoxin derivative, comprising:
- operably linked to a promoter, at least one nucleic acid molecules having at least 70% sequence identity to a sequence selected from SEQ ID NOS:
- 4-8 and encoding at least one polypeptide involved in the biosynthesis of podophyllotoxin intermediates and derivatives,
- wherein the biosynthesis is initiated with a starting material suitable to produce the podophyllotoxin intermediate or podophyllotoxin derivative, and
- wherein the biosynthesis is completed with the recovery of the podophyllotoxin intermediate or podophyllotoxin derivative from the host cell.
1 more element
Dependencies are inferred from the claim text.