Chemical engineering processes and apparatus for the synthesis of compounds
AssigneeTeewinot Technologies Limited
InventorsRichard Peet, Malcolm J. Kavarana, Robert Winnicki, Marc Donsky, Mingyang Sun
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Abstract
The present invention provides methods for producing cannabinoids and cannabinoid analogs as well as a system for producing these compounds. The inventive method is directed to contacting a compound according to Formula I or Formula II with a cannabinoid synthase. Also described is a system for producing cannabinoids and cannabinoid analogs by contacting a THCA synthase with a cannabinoid precursor and modifying at least one property of the reaction mixture to influence the quantity formed of a first cannabinoid relative to the quantity formed of a second cannabinoid.
Claims9
A method of producing one or more cannabinoids comprising:
- reacting 3-(3,7-dimethylocta-2,6-diene-1-yl)-2,4-dihydroxy-6-propoyl-1-benzoic acid (CBGVA)
- with a recombinant cannabinoid synthase as a catalyst in a reaction mixture, wherein the cannabinoid synthase comprises a THCA synthase or a CBDA synthase;
- controlling a property of the reaction mixture to modify the amount of the one or more cannabinoids;
- wherein the reaction mixture comprises one or more solvents of dimethyl sulfoxide (DMSO), dimethylformamide (DMF), iso-propoyl alcohol and cyclodextrin, and wherein the amount of the solvent in the reaction mixture is between 5% and 30% (w/v);
- wherein the pH of the reaction mixture is between 4.0 to 6.0.
Dependencies are inferred from the claim text.