Methods and compositions for treating genetic eye diseases
AssigneeUniversity of Iowa Research Foundation
InventorsBeverly L Davidson, Yong Hong Chen, Alberto Auricchio
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Abstract
The present disclosure provides targeting peptides and vectors containing a sequence that encodes targetting peptides that deliver agents, to the eye. The present inventors have discovered peptides that function to target agents, such as viral vectors, to ocular cells. The present disclosure describes a method to utilize these novel peptides to direct, for example, viral capsids to the cell type of interest. In this instance, ocular cells (such as retinal cells) are targeted by the identified peptides. Vectors harboring capsid proteins modified to include such peptides can be used to provide therapeutic agents to the eye.
Claims21
A modified adeno-associated virus (AAV) capsid protein comprising an ocular cell targeting peptide, wherein the targeting peptide comprises a sequence up to 10 amino acids in length that comprises GSTPPPM (SEQ ID NO:
- 1), in an amino to carboxy orientation or in a carboxy to amino orientation, and wherein the targeting peptide targets an AAV to an ocular cell.
Dependencies are inferred from the claim text.