Back to results
US 10,472,649 B2Granted
Methods and compositions for the activation of gamma-delta T-cells
AssigneeAmerican Gene Technologies International Inc.
InventorsCharles David Pauza, Haishan Li, Tyler Lahusen, Mei-Ling Liou
Life of this patent
Estimating the term…
Abstract
The present invention relates generally to methods and compositions for gene therapy and immunotherapy that activate gamma delta T-cells, and in particular, can be used in the treatment of various cancers and infectious diseases.
Claims6
An immunotherapy-based system comprising:
- (i) at least one helper plasmid comprising DNA sequences for expressing a functional protein derived from each of a gag, pol, and rev gene;
- (ii) an envelope plasmid comprising a DNA sequence for expressing an envelope protein capable of infecting a target cell;
- and
- (iii) a therapeutic vector comprising:
- at least one encoded shRNA that, when expressed, inhibits production of farnesyl diphosphate synthase,
- or,
- at least one encoded microRNA that, when expressed, inhibits production of farnesyl diphosphate synthase.
4 more elements
Dependencies are inferred from the claim text.