Mutant microorganism producing L-aspartic acid derivatives, and method for producing L-aspartic acid derivatives using same
AssigneeKorea Advanced Institute of Science and Technology
InventorsSang Yup Lee, Tong Un Chae, Chan Woo Song
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Abstract
The present invention relates to a mutant organism having the ability to produce aspartic acid derivatives, wherein a gene encoding the glyoxylate shunt regulator and a gene encoding fumarase are deleted and a gene encoding aspartase is overexpressed compared to that in a wild-type strain, and to a method for producing L-aspartic acid derivatives using the same. According to the present invention, various aspartic acid derivatives, including L-alanine, 3-aminopropionic acid, threonine, 1,3-diaminopropane, lysine, methionine, 3-hydroxypropionic acid, cadaverine, 5-aminovaleric acid, etc., can be produced by biological methods.
Claims17
A mutant microorganism having the ability to produce L-aspartic acid derivatives from sugar, wherein a gene encoding the glyoxylate shunt regulator and a gene encoding fumarase are deleted, and a gene encoding aspartase is overexpressed compared to that in a wild-type strain.
A mutant microorganism having the ability to produce 3-aminopropionic acid from sugar, wherein a ic1R gene and a gene encoding fumarase are deleted, a aspA gene is overexpressed compared to that in a wild-type strain, and a gene encoding aspartate dehydroxylase is introduced.
A mutant microorganism having the ability to produce 1,3-diaminopropane from sugar, wherein a ic1R gene and a gene encoding fumarase are deleted, a aspA gene is overexpressed compared to that in a wild-type strain, and genes encoding 2-ketoglutarate 4-aminotransferase and L-2,4-diaminobutyrate decarboxylase are introduced.
A mutant microorganism having the ability to produce 3-hydroxypropionic acid from sugar, wherein a ic1R gene and a gene encoding fumarase are deleted, a aspA gene is overexpressed compared to that in a wild-type strain, and a gene encoding aspartate dehydroxylase, a gene encoding 3-hydroxypropionate/3-hydroxyisobutyrate dehydrogenase or malonic semialdehyde reductase, and a gene encoding beta alanine pyruvate transaminase, are introduced.
Dependencies are inferred from the claim text.