Methods of treating brain edema
OwnerTerrance P. Snutch, Ravi Rungta +3inventors
InventorsTerrance P. Snutch, Ravi Rungta, Choi Hyun, John Tyson, Brian Macvicar
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Abstract
Provided are methods for treating or preventing brain edema in a subject by administering an inhibitor of SLC26A11 to the subject. Also included are methods for preventing cell death, cell swelling, or elevated internal concentration of chloride ions in a cell by contacting the cell with an inhibitor of SLC26A11.
Claims14
A method for reducing swelling of a brain cell, comprising specifically inhibiting SLC26A11-mediated Cl− import in the cell, wherein the SLC26A11-mediated Cl− import in the brain cell is inhibited by reducing the level of SLC26A11 expression in the cell via delivery of one or more siRNA targeting SLC26A11.
A method for reducing internal Cl− concentration in a brain cell, comprising specifically inhibiting SLC26A11-mediated Cl− import in the cell, wherein the SLC26A11-mediated Cl− import in the brain cell by reducing the level of SLC26A11 expression in the cell via delivery of one or more siRNA targeting SLC26A11.
A method of treating brain edema in a subject comprising specifically inhibiting SLC26A11-mediated Cl− import in a brain cell of the subject, wherein the SLC26A11-mediated Cl− import in the brain cell is inhibited by reducing the level of SLC26A11 expression in the cell via delivery of one or more siRNA targeting SLC26A11.
Dependencies are inferred from the claim text.