Anti-connexin compounds targeted to connexins and methods of use thereof
AssigneeOcunexus Therapeutics, Inc.
InventorsWilda Laux, Colin Richard Green
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Abstract
Methods and compositions for modulating the activities of connexins are provided, including, for example, for use in post-surgical, trauma, or tissue engineering applications. These compounds and methods can be used therapeutically, for example, to reduce the severity of adverse effects associated diseases and disorders where localized disruption in direct cell-cell communication is desirable.
Claims12
A method for treating a subject for corneal trauma, comprising topically administering to the eye of said subject a composition comprising a pluronic F127 gel, phosphate buffered saline, and a connexin 43-downregulating amount of a connexin 43 antisense compound, wherein said connexin 43 antisense compound is 5′ GTA ATT GCG GCA AGA ATT GTT TCT GTC 3′ (SEQ ID NO:
- 1).
Dependencies are inferred from the claim text.