Methods and compositions for modlating apolipoprotein (A) expression
AssigneeIonis Pharmaceuticals, Inc.
InventorsRosanne M. Crooke, Mark J. Graham, Susan M. Freier
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Abstract
Disclosed herein are antisense compounds and methods for decreasing apo(a) to treat, prevent, or ameliorate diseases, disorders or conditions related to apo(a) or Lp(a). Certain diseases, disorders or conditions related to apo(a) or Lp(a) include inflammatory, cardiovascular and/or metabolic diseases, disorders or conditions. The antisense compounds disclosed herein can be used to treat such diseases, disorders or conditions in an individual in need thereof.
Claims18
A method of treating, preventing, or slowing progression of a disease disorder or condition in a subject comprising administering to the subject a compound comprising a modified oligonucleotide consisting of 17 to 30 linked nucleosides and having a nucleobase sequence comprising at least 17, at least 18, at least 19, or 20 contiguous nucleobases of any of the nucleobase sequences of SEQ ID NO:
- 14, 16, 17, 18, 28, 47, 82, 107.
Dependencies are inferred from the claim text.