Photostable fluorescent polymeric tandem dyes including luminescent metal complexes
AssigneeBecton, Dickinson and Company
InventorsRobert J. Radford, Douglas B. Sherman, Jody Martin, James Ghadiali
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Abstract
Photostable polymeric tandem dyes are provided. The photostable polymeric tandem dyes include a water soluble light harvesting multichromophore and a luminescent metal complex covalently linked to the multichromophore and in energy-receiving proximity therewith. Also provided are labelled specific binding members that include the subject dyes. Methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule in which the subject polymeric tandem dyes find use are also provided. Systems and kits for practicing the subject methods are also provided.
Claims21
A photostable polymeric tandem dye comprising:
- a water soluble light harvesting multichromophore comprising a block copolymer comprising a conjugated segment comprising a fluorene co-monomer substituted with at least one water solubilizing group (WSG);
- and
- a luminescent ruthenium complex covalently linked to the multichromophore in energy-receiving proximity therewith.
Dependencies are inferred from the claim text.