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US 10,472,427 B2Granted
Heterodimeric proteins
AssigneeXencor, Inc.
InventorsJohn Desjarlais, Gregory Moore, Rumana Rashid, Matthew Bernett
Life of this patent
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Abstract
The invention provides heterodimeric antibodies comprising a first heavy chain comprising a first Fc domain and a single chain Fv region that binds a first antigen. The heterodimeric antibodies also comprise a second heavy chain comprising a second Fc domain, a first variable heavy chain and a first variable light chain, wherein the first and second Fc domains are different.
Claims14
A heterodimeric protein comprising:
- a) a first monomer comprising a first variant Fc domain, and
- b) a second monomer comprising a second variant Fc domain,
- wherein said first and second variant Fc domains comprise amino acid variant set L368D and S364K, according to the EU index as in Kabat.
A heterodimeric protein comprising:
- a) a first monomer comprising:
- i) a first variant Fc domain;
- and
- ii) a single chain Fv (scFv) region that binds a first antigen;
- and
- b) a second monomer comprising a VH-CH1-hinge-CH2-CH3 region, wherein said CH2-CH3 is a second variant Fc domain;
- and
- c) third monomer comprising:
- i) a variable light chain;
- and
- ii) a constant light chain;
- wherein said first and second variant Fc domains comprise amino acid variant set L368D and S364K, according to the EU index as in Kabat.
9 more elements
Dependencies are inferred from the claim text.