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US 10,472,423 B2Granted
IL2Rbeta/common gamma chain antibodies
AssigneeAgency for Science, Technology and Research
InventorsCheng-I Wang, Peter Brauer, Siok Ping Yeo, Hwee Ching Tan, John Edward Connolly
Life of this patent
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Abstract
Anti-CD122 and/or γc antibodies and fragments thereof are disclosed. Also disclosed are compositions comprising such antibodies and fragments, and uses and methods using the same.
Claims5
An isolated antibody or antigen binding fragment, which specifically binds to CD122 and, comprises:
- (i) a light chain variable region comprising the following CDRs:
- (SEQ ID NO:
- 2)
- LC-CDR1:
- TGTSSDIGHYDFVS,
- (SEQ ID NO:
- 3)
- LC-CDR2:
- DINNRPS,
- and
- (SEQ ID NO:
- 4)
- LC-CDR3:
- SAYTSSDTLV;
- and
- (ii) a heavy chain variable region comprising the following CDRs:
- (SEQ ID NO:
- 36)
- HC-CDR1:
- NYYMH,
- (SEQ ID NO:
- 37)
- HC-CDR2:
- AIMPSRGGTSYPQKFQG,
- and
- (SEQ ID NO:
- 38)
- HC-CDR3:
- GEYYYDSSGYYY.
26 more elements
Dependencies are inferred from the claim text.