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US 10,472,421 B2Granted
Method for expansion of a population of cells with IL2R beta/common gamma chain antibodies
AssigneeAgency for Science, Technology and Research
InventorsCheng-I Wang, Peter Brauer, Siok Ping Yeo, Hwee Ching Tan, John Edward Connolly
Life of this patent
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Abstract
Anti-CD122 and/or γc antibodies and fragments thereof are disclosed. Also disclosed are compositions comprising such antibodies and fragments, and uses and methods using the same.
Claims7
A method for expanding a population of cells expressing an IL-2 receptor comprising a complex of CD122 and common γ chain (γc), comprising contacting cells expressing the IL-2 receptor with an antibody or antigen binding fragment which is an IL-2 receptor agonist, and comprises:
- (a) an antigen-binding fragment which binds to CD122, comprising:
- (i) a light chain variable region comprising the following CDRs:
- LC-CDR1:
- (SEQ ID NO:
- 2)
- TGTSSDIGHYDFVS,
- LC-CDR2:
- (SEQ ID NO:
- 3)
- DINNRPS, and
- LC-CDR3:
- (SEQ ID NO:
- 4)
- SAYTSSDTLV;
- and
- (ii) a heavy chain variable region comprising the following CDRs:
- HC-CDR1:
- (SEQ ID NO:
- 36)
- NYYMH,
- HC-CDR2:
- (SEQ ID NO:
- 37)
- AIMPSRGGTSYPQKFQG, and
- HC-CDR3:
- (SEQ ID NO:
- 38)
- GEYYYDSSGYYY;
- and
- (b) an antigen-binding fragment which binds to γc, comprising:
- (i) a light chain variable region comprising the following CDRs:
- LC-CDR1:
- (SEQ ID NO:
- 68)
- RSSQSLLHSNGYNYLD,
- LC-CDR2:
- (SEQ ID NO:
- 69)
- LGSNRDS, and
- LC-CDR3:
- (SEQ ID NO:
- 70)
- MQGTHWPWT;
- and
- (ii) a heavy chain variable region comprising the following CDRs:
- HC-CDR1:
- (SEQ ID NO:
- 48)
- GYYWS,
- HC-CDR2:
- (SEQ ID NO:
- 49)
- EINHSGSTNYNPSLKS, and
- HC-CDR3:
- (SEQ ID NO:
- 77)
- SPGGYSGGYFQH.
54 more elements
Dependencies are inferred from the claim text.