Immune response modifier conjugates

An IRM conjugate comprising:

• a first linker having a first functional group covalently attached to an IRM compound having immunomodulatory activity, at a site on the IRM compound selected to preserve at least a portion of the immunomodulatory activity of the IRM compound, thereby forming an IRM moiety;
• and
• a second moiety having biological activity and a second functional group that is bound to the IRM moiety by way of a covalent bond between the first functional group and the second functional group;
• wherein IRM conjugate possesses IRM activity and the biological activity of the second moiety;
• and wherein the covalent bond that is a reaction product of the first functional group and the second functional group comprises a disulfide linkage, a thioether linkage, a hydrazone linkage, an oxime linkage, a urea linkage, a thiourea linkage, a hydrazine linkage, a hydroxyl amine linkage, or a nitrone linkage.