Antibody molecules to TIM-3 and uses thereof

A nucleic acid molecule comprising a nucleotide sequence selected from:

• a nucleotide sequence that encodes a heavy chain variable region (VH), a nucleotide sequence that encodes a light chain variable region (VL), or a nucleotide sequence that encodes both a VH and a VL of an antibody molecule that binds to human T-cell immunoglobulin domain and mucin domain 3 (TIM-3), wherein the antibody molecule comprises:
• (a) a VH comprising a VHCDR1 amino acid sequence of SEQ ID NO:
• 9;
• a VHCDR2 amino acid sequence of SEQ ID NO:
• 10;
• and a VHCDR3 amino acid sequence of SEQ ID NO:
• 5;
• and a VL comprising a VLCDR1 amino acid sequence of SEQ ID NO:
• 12, a VLCDR2 amino acid sequence of SEQ ID NO:
• 13, and a VLCDR3 amino acid sequence of SEQ ID NO:
• 14;
• (b) a VH comprising a VHCDR1 amino acid sequence of SEQ ID NO:
• 3;
• a VHCDR2 amino acid sequence of SEQ ID NO:
• 4;
• and a VHCDR3 amino acid sequence of SEQ ID NO:
• 5;
• and a VL comprising a VLCDR1 amino acid sequence of SEQ ID NO:
• 6, a VLCDR2 amino acid sequence of SEQ ID NO:
• 7, and a VLCDR3 amino acid sequence of SEQ ID NO:
• 8;
• (c) a VH comprising a VHCDR1 amino acid sequence of SEQ ID NO:
• 9;
• a VHCDR2 amino acid sequence of SEQ ID NO:
• 25;
• and a VHCDR3 amino acid sequence of SEQ ID NO:
• 5;
• and a VL comprising a VLCDR1 amino acid sequence of SEQ ID NO:
• 12, a VLCDR2 amino acid sequence of SEQ ID NO:
• 13, and a VLCDR3 amino acid sequence of SEQ ID NO:
• 14;
• (d) a VH comprising a VHCDR1 amino acid sequence of SEQ ID NO:
• 3;
• a VHCDR2 amino acid sequence of SEQ ID NO:
• 24;
• and a VHCDR3 amino acid sequence of SEQ ID NO:
• 5;
• and a VL comprising a VLCDR1 amino acid sequence of SEQ ID NO:
• 6, a VLCDR2 amino acid sequence of SEQ ID NO:
• 7, and a VLCDR3 amino acid sequence of SEQ ID NO:
• 8;
• (e) a VH comprising a VHCDR1 amino acid sequence of SEQ ID NO:
• 9;
• a VHCDR2 amino acid sequence of SEQ ID NO:
• 31;
• and a VHCDR3 amino acid sequence of SEQ ID NO:
• 5;
• and a VL comprising a VLCDR1 amino acid sequence of SEQ ID NO:
• 12, a VLCDR2 amino acid sequence of SEQ ID NO:
• 13, and a VLCDR3 amino acid sequence of SEQ ID NO:
• 14;
• or
• (f) a VH comprising a VHCDR1 amino acid sequence of SEQ ID NO:
• 3;
• a VHCDR2 amino acid sequence of SEQ ID NO:
• 30;
• and a VHCDR3 amino acid sequence of SEQ ID NO:
• 5;
• and a VL comprising a VLCDR1 amino acid sequence of SEQ ID NO:
• 6, a VLCDR2 amino acid sequence of SEQ ID NO:
• 7, and a VLCDR3 amino acid sequence of SEQ ID NO:
• 8.