US 10,472,415 B2Granted

Antibodies specific for hyperphosphorylated tau and methods of use

AssigneeH. Lundbeck A/S

InventorsJan Torleif Pedersen, Kristian Kjærgaard, Lars Østergaard Pedersen, Abdur-Rasheed Asuni, Nina Helen Rosenqvist, Justus Claus Alfred Daechsel, Karsten Juhl, Lena Tagmose, Mauro Marigo, Thomas Jensen, Søren Christensen, Laurent David, Christiane Volbracht, Lone Helboe

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Abstract

The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.

Claims3

Dependent claims

A monoclonal antibody comprising:

(a) a Light Chain CDR1 having the amino acid sequence of SEQ ID NO:31;
(b) a Light Chain CDR2 having the amino acid sequence of SEQ ID NO:4;
(c) a Light Chain CDR3 having the amino acid sequence of SEQ ID NO:5;
(d) a Heavy Chain CDR1 having the amino acid sequence of SEQ ID NO:6;
(e) a Heavy Chain CDR2 having the amino acid sequence of SEQ ID NO:7;
and
(f) a Heavy Chain CDR3 having the amino acid sequence of SEQ ID NO:8.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application: 15/645,442Filed 10 Jul 2017
Priority: DK 2016 0041612 Jul 2016
Published: US 2018/0016330 A118 Jan 2018
Granted: 12 Nov 2019
Term ends: Not estimatedThe source records don’t support an estimate.

Classification29 codes

C07K 16/18
Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies: against material from animals or humans
A61K 39/395
Medicinal preparations containing antigens or antibodies: antibodies ; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61K 49/00
Preparations for testing in vivo
A61P 9/10
Drugs for disorders of the cardiovascular system: for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary…