Bispecific multivalent fusion proteins
AssigneesThe United States of America, as represented by the Secretary, Department of Health and Human Services, Fudan University
InventorsDimiter S. Dimitrov, Weizao Chen, Tianlei Ying
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Abstract
The invention provides a construct comprising two or more fusion proteins of Formulas (I)-(IV): A-(optional linker)-C-(optional linker)-B (Formula I), B-(optional linker)-D-(optional linker)-E-(optional linker)-B (Formula II), A-(optional linker)-C (Formula III), and B-(optional linker)-D-(optional linker)-E (Formula IV), wherein A denotes an antibody or antibody fragment, B denotes a single domain CD4, C denotes an immunoglobulin light chain constant region D denotes an immunoglobulin heavy chain constant region, and E denotes an Fc region or a portion thereof that is optionally defucosylated.
Claims16
A construct comprising
- two fusion proteins of A-(optional linker)-C(Formula III), and
- two fusion proteins of B-(optional linker)-D-(optional linker)-E-(optional linker)-B (Formula II),
- wherein A is an antibody or antibody fragment and B is a single domain CD4,
- wherein C is a modified immunoglobulin light chain constant region comprising one of SEQ ID NOs:
- 29-34,
- wherein D is modified immunoglobulin heavy chain constant region comprising one of SEQ ID NOs:
- 22-27, and
- wherein E is an Fc region or portion thereof.
Dependencies are inferred from the claim text.