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US 10,472,393 B2Granted
Method for inhibiting ADAM proteases with cyclic peptides
AssigneesCancer Research Technology Limited, King's College London
InventorsJoerg Bartsch, Garrit Koller
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Abstract
The invention relates to a method for inhibiting an ADAM protease, comprising inhibiting binding to an integrin-binding loop of a disintegrin domain in the ADAM protease. Also provided are cyclic peptides which inhibit binding to an integrin-binding loop of an ADAM protease, as well as associated pharmaceutical compositions, uses and methods of treatment.
Claims2
A method for inhibiting an ADAM protease, comprising contacting the ADAM protease with a cyclic peptide of formula I:
- wherein X0, X1, X2 and X3 each independently represents an amino acid residue;
- wherein each amino acid residue in the cyclic peptide is joined by a peptide bond;
- wherein each X0 may be the same or different;
- wherein X1, X2, and X3 are selected such that the cyclic peptide comprises one of the following amino acid sequences:
- KDM, ARQ, DSD, NAT, VRQ, and TDD;
- and wherein n is 0 to 4;
- or a pharmaceutically acceptable salt thereof.
4 more elements
Dependencies are inferred from the claim text.