Methods and compositions using ADAM10 inhibitors to treat bacterial infections
AssigneesThe University of Chicago, SRI International
InventorsJuliane Bubeck Wardenburg, Katherine Weh, Leyi Gong
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Abstract
Certain embodiments are directed to compositions and methods of inhibiting a pathogenic bacterial infection involving ADAM10, specifically a method for treating pore-forming toxin-inducted pathology caused by exposure to staphylococcus in a subject, comprising administering an effective amount of a ADAM10 inhibitor to a patient. The methods include treating pneumonia or inhibiting disruption to epithelial barrier in a subject, having or at risk of developing staphylococcal infection.
Claims10
A compound of the formula:
- wherein:
- R1 is hydrogen, alkyl, halogen, haloalkyl, alkenyl, or alkynyl;
- R2 is hydrogen, alkyl, benzyl, aryl, aralkyl, functionalized aralkyl, alkenyl, or alkynyl;
- R3 is hydrogen, alkyl, benzyl, aryl, alkenyl, or alkynyl;
- R4 is (tetrahydrofuran-2-yl)methyl;
- and
- R5 is hydrogen or methyl,
- or a salt, prodrug, enantiomer, or diastereomer thereof.
A compound of the formula:
- wherein:
- R2 is hydrogen, alkyl, benzyl, aryl, aralkyl, functionalized aralkyl, alkenyl, or alkynyl;
- R3 is hydrogen, alkyl, benzyl, aryl, alkenyl, or alkynyl;
- R4 is (tetrahydrofuran-2-yl)methyl;
- and
- R5 is hydrogen or methyl,
- or a salt, prodrug, enantiomer, or diastereomer thereof.
A compound of the formula:
- wherein:
- R2 is hydrogen, alkyl, benzyl, aryl, aralkyl, functionalized aralkyl, alkenyl, or alkynyl;
- R3 is hydrogen, alkyl, benzyl, aryl, alkenyl, or alkynyl;
- R4 is (tetrahydrofuran-2-yl)methyl;
- and
- R5 is hydrogen or methyl,
- or a salt, prodrug, enantiomer, or diastereomer thereof.
A compound of the formula:
- wherein:
- R2 is hydrogen, alkyl, benzyl, aryl, aralkyl, functionalized aralkyl, alkenyl, or alkynyl;
- R3 is hydrogen, alkyl, benzyl, aryl, alkenyl, or alkynyl;
- R4 is (tetrahydrofuran-2-yl)methyl;
- and
- R5 is hydrogen or methyl,
- or a salt, prodrug, enantiomer, or diastereomer thereof.
An ADAM10 inhibitor of the formula:
- wherein:
- R1 is hydrogen, alkyl, halogen, haloalkyl, alkenyl, or alkynyl;
- R2 is hydrogen, alkyl, benzyl, aryl, aralkyl, functionalized aralkyl, alkenyl, or alkynyl;
- R3 is hydrogen, alkyl, benzyl, aryl, alkenyl, or alkynyl;
- R4 is (tetrahydrofuran-2-yl)methyl;
- and
- R5 is hydrogen or methyl,
- or a salt, prodrug thereof.
Dependencies are inferred from the claim text.