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US 10,472,379 B2Granted
Ruthenium-sphingomyelin complexes and methods for their use in the treatment of tumors
OwnerMerrill Garnettinventor
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Abstract
The described invention provides a compound comprising an organometallic complex comprising a core of ruthenium and sphingomyelin, with the option of added zinc, that, in a therapeutic amount, through further connections with contributing organic ligands, are effective as chemotherapeutic agents that have an anti-tumor or anti-cancer effect on a tumor comprising tumor cells including a cytotoxic effect on of the tumor cells, inhibition of the growth of the tumor comprising the tumor cells, inhibition of migration of the tumor cells, or any combination of these effects.
Claims40
An organometallic complex comprising:
- a first lipid component comprising a carbonyl functional group, an alcohol functional group, or a combination thereof;
- a ruthenium component;
- a first amino acid component comprising a carbonyl functional group, a methyl functional group, or combination thereof;
- wherein the ruthenium component is associated with the first lipid component via the carbonyl functional group, alcohol functional group, or combination thereof, of the first lipid component;
- wherein the ruthenium component is associated with the first amino acid component via the carbonyl functional group, methyl functional group, or combination thereof, of the first amino acid;
- wherein the first lipid component, the ruthenium component and first amino acid component are in association to form a first sub complex;
- the organometallic complex further comprising a macromolecule component;
- the organometallic complex further comprising:
- a second lipid component comprising a methyl functional group, an alkene functional group, a carboxylic acid functional group, or a combination thereof;
- a metal component;
- a second amino acid component comprising a carboxylic acid functional group, an amine functional group, or a combination thereof;
- and
- a third amino acid component comprising an amine functional group;
- wherein the metal component is associated with the second lipid component via the methyl functional group, the alkene functional group, the carboxylic acid functional group, or combination thereof, of the second lipid component;
- wherein the metal component is associated with the second amino acid component via the amine functional group, carboxylic acid functional group, or combination thereof, of the second amino acid;
- wherein the third amino acid component is associated with the second lipid component via an association of the alkene functional group, the methyl functional group, the carboxylic acid function group, or combination thereof, of the second lipid with the amine functional group of the third amino acid;
- wherein, the second lipid component, metal component, second amino acid component, and third amino acid component are in association to form a second sub complex;
- wherein the first sub complex associates with the second sub complex via the metal component and the carbonyl functional group or the methyl functional group of the first amino acid to form a single larger complex;
- wherein the macromolecule component associates at least with the first sub complex;
- wherein the complex does not comprise palladium.
17 more elements
An organometallic complex of Formula I:
- (First lipid)a(Ru)b(first amino acid)c(Zn)d(second amino acid)e(second lipid)f(third amino acid)g(macromolecule)h
- wherein the first lipid component comprises a membrane lipid or a derivative thereof;
- the Ru signifies a ruthenium component;
- the first, second, and third amino acid components comprise an amino acid or a derivative thereof;
- the Zn signifies a zinc component;
- the second lipid component comprises a hydrocarbon chain of from 2 to twenty carbon atoms wherein at one end of the hydrocarbon chain (ω carbon) is a methyl group and at the other end (α carbon) is a carboxyl group, or a derivative thereof;
- the macromolecule component comprises a polypeptide chain;
- wherein a, b, c, and h are at least 1;
- and d, e, f, and g are 0 or 1;
- wherein e, f, and g are 0 when d is 0, and g is 0 when f is 0;
- wherein the Ru component structurally associates the first lipid component with the first amino acid component;
- the Zn component structurally associates the first amino acid component with one or more of the second amino acid component or second lipid component;
- the third amino acid component is associated with the second lipid component;
- the macromolecule component associates with one or more of the first lipid component, the Ru component, the first amino acid component, the Zn component, the second amino acid component, the third amino acid component, or the second lipid component.
11 more elements
Dependencies are inferred from the claim text.