HIV-1 protease inhibitors and uses thereof

A compound of the formula (I):

• or a pharmaceutically acceptable salt, polymorph, prodrug, solvate or ate thereof, wherein:
• n is an integer from 1 to 3;
• X and X1 are each, independently, (—CH2—)m, wherein m is 1 or 2;
• R1 is —N3 or —NR52, wherein each R5 is, independent, H, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl or a nitrogen protecting group;
• R7 is H or unsubstituted or substituted alkyl or R1 and R7, together with the carbon atom to which they are attached, form a heterocycle;
• R2 is unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkoxy, unsubstituted or substituted hydroxyalkyl, halo, unsubstituted or substituted heterocyclylaltyloxy, —O—(CH2)0-2P(O)(OR6)2, wherein each R6 is independently H or unsubstituted or substituted alkyl or substituted or unsubstituted aryl or R1 is —NR52, wherein one R5 and one R2 are joined to represent the group —(CH2)p(CHCH)d(CH2)qO— wherein p is an integer from 0 to 5, d is 0 or 1, and q is an integer from 0 to 5;
• R3 is substituted or unsubstituted alkyl;
• and
• R4 is unsubstituted or substituted aryl, unsubstituted or substituted benzthiazole, unsubstituted or substituted benzoxazole, unsubstituted or substituted benzofuranyl or unsubstituted or substituted indolyl.