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US 10,472,359 B2Granted
Pharmaceutical compositions comprising 4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-1-(4-fluorophenyl) butan-1-one for inhibiting serotonin reuptake transporter activity
AssigneeIntra-Cellular Therapies, Inc.
InventorsPeng Li, Qiang Zhang, Robert Davis, Lawrence P. Wennogle
Life of this patent
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Abstract
The invention relates to pharmaceutical compositions comprising 4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-1-(4-fluorophenyl)butan-1-one in toluenesulfonic acid addition salt form: and methods of use in the treatment of diseases involving the 5-HT2A receptor pathway, the serotonin transporter (SERT) pathway and/or the dopamine D2 receptor pathway signaling systems.
Claims20
A pharmaceutical composition comprising:
- (i) a compound of Formula Q:
- wherein:
- X is —N(CH3)—;
- and
- Y is —C(═O)—;
- in toluenesulfonic acid addition salt form;
- and
- (ii) a polymeric matrix.
5 more elements
Dependencies are inferred from the claim text.