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US 10,472,354 B2Granted
1,3-thiazol-2-yl substituted benzamides
AssigneeBayer Aktiengesellschaft
InventorsAdam James Davenport, Nico Bräuer, Oliver Martin Fischer, Andrea Rotgeri, Antje Rottmann, Ioana Neagoe, Jens Nagel, Anne-Marie Godinho-Coelho, Jürgen Klar
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Abstract
The present invention relates to 1,3-thiazol-2-yl substituted benzamide compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neurogenic disorder, as a sole agent or in combination with other active ingredients.
Claims13
A compound of formula (I):
- wherein:
- R1 is a halogen atom, C1-C4-alkyl or C3-C6-cycloalkyl,
- wherein C1-C4-alkyl is optionally substituted with 1-5 halogen atoms which are the same or different;
- R2 is —C2-C6-alkyl-OR4, —(CH2)q—(C3-C7-cycloalkyl), —(CH2)q-(6- to 12-membered heterobicycloalkyl), —(CH2)q-(4- to 7-membered heterocycloalkyl), —(CH2)q-(5- to 10-membered heteroaryl) or —C2-C6-alkynyl,
- wherein said —(CH2)q—(C3-C7-cycloalkyl), —(CH2)q-(6- to 12-membered heterobicyclo-alkyl) and —(CH2)q-(4- to 7-membered heterocycloalkyl) are optionally substituted with one or more substituents, which are the same or different, at any ring carbon atom and selected from the group consisting of C1-C4 alkyl optionally substituted with 1-5 halogen atoms which are the same or different, a halogen atom, —NRaRb, COOR5 and oxo (═O),
- wherein any ring nitrogen atom, if present in said —(CH2)q-(6- to 12-membered heterobicycloalkyl) and (CH2)q-(4- to 7-membered heterocycloalkyl), is substituted with Rc, and
- wherein said —(CH2)q-(5- to 10-membered heteroaryl) is optionally substituted with one or more substituents, which are the same or different, and selected from the group consisting of C1-C4-alkyl optionally substituted with 1-5 halogen atoms which are the same or different, a halogen atom, —NRaRb and COOR5;
- R3 is hydrogen or C1-C4-alkyl optionally substituted with 1-5 halogen atoms which are the same or different;
- R4 and R5 are independently hydrogen or C1-C4-alkyl;
- Ra and Rb are independently hydrogen or C1-C4-alkyl;
- Rc is hydrogen, C1-C4-alkyl optionally substituted with 1-5 halogen atoms which are the same or different, —C(O)O—C1-C4-alkyl, or —C(O)—C1-C4-alkyl;
- A is 5- to 10-membered heteroaryl which is optionally substituted with one or more substituents, which are the same or different, and selected from the group consisting of a halogen atom, C1-C3-alkyl, and C1-C3-alkoxy,
- wherein said C1-C3-alkyl and C1-C3-alkoxy are optionally substituted with 1-5 halogen atoms which are the same or different;
- and
- q is an integer of 0, 1, or 2.
12 more elements
Dependencies are inferred from the claim text.