Salt and crystal forms of PLK-4 inhibitor
AssigneeUniversity Health Network
InventorsPeter Brent Sampson, Miklos Feher, Heinz W. Pauls
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Abstract
A fumarate salt and a maleate salt of compound (I) represented by the following structural formula, as well as their corresponding pharmaceutical compositions, are disclosed. Particular single crystalline forms of 1:1 compound (I) fumarate and 1:1 compound (I) maleate are characterized by a variety of properties and physical measurements. Methods of preparing specific crystalline forms of 1:1 compound (I) fumarate and 1:1 compound (I) maleate are also disclosed. The present invention also provides methods of treating a subject with a cancer.
Claims20
A fumarate salt of compound (I) represented by the following structural formula:
- wherein the molar ratio between compound (I) and fumaric acid is 1:1.
Dependencies are inferred from the claim text.