Potent gamma-secretase modulators

A compound of Formula (A):

• or a pharmaceutically acceptable salt thereof, wherein,
• L1 is selected from the group consisting of C(O), C(R1)(R2), substituted or unsubstituted —C2-6 alkylene-, and substituted or unsubstituted —C3-6 cycloalkylene-;
• Z is selected from the group consisting of halo, CN, OH, C1-6 alkyl, C1-6 alkoxy, C1-3 haloalkyl, C1-3 haloalkoxy, amino, C1-3 alkylamino, di(C1-3 alkyl)amino, substituted or unsubstituted C3-6 cycloalkyl, substituted or unsubstituted C4-6 heterocycloalkyl, substituted or unsubstituted heteroaryl, and a group of Formula (Z-1):
• or L1 is absent and Z is selected from the group consisting of substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, and substituted or unsubstituted heteroaryl;
• R1 and R2 are independently selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, COOR1A, and —CONR1AR1B, or
• R1 and R2 are optionally joined together to form a substituted or unsubstituted cycloalkyl;
• R3 is selected from the group consisting of hydrogen, halogen, —CF3, —CN, —OR3A, —NR3AR3B, —COOR3A, —CONR3AR3B, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl;
• R4 is selected from the group consisting of hydrogen, halogen, —CF3, —CN, —OR4A, —NR4AR4B, —COOR4A, —CONR4AR4B, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl;
• or
• R3 and R4 are optionally joined together to form a substituted or unsubstituted cycloalkyl;
• each R5 is independently selected from the group consisting of hydrogen, halogen, —CF3, —CN, —OR5A, —NR5AR5B, —COOR5A, —CONR5AR5B, —SR5A, —OCF3, —OCHF2, substituted or unsubstituted alkyl, and substituted or unsubstituted heteroalkyl;
• R6 and R7 are independently substituted or unsubstituted C1-C5 alkyl;
• R1A, R1B, R3A, R3B, R4A, R4B, R5A, and R5B are independently selected from the group consisting of hydrogen, —OH, —NH2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl;
• or
• R1A and R1B, R3A and R3B, R4A and R4B, or R5A and R5B are independently optionally joined together to independently form a substituted or unsubstituted heterocycloalkyl, or substituted or unsubstituted heteroaryl;
• R8 is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, and substituted or unsubstituted heteroalkyl;
• and
• z1 is an integer of 0, 1, 2, 3, 4, or 5.