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US 10,472,342 B2Granted
Compounds and compositions for inhibition of FASN
AssigneeFORMA Therapeutics, Inc.
InventorsKenneth W. Bair, David R. Lancia, Jr., Hongbin Li, James Loch, Wei Lu, Matthew W. Martin, David S. Millan, Shawn E. R. Schiller, Mark J. Tebbe
Life of this patent
Estimating the term…
Abstract
The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:
Claims25
A compound of formula (I-B)
- or a pharmaceutically acceptable salt thereof, wherein
- Ar1 is a 6-member monocyclic aryl or 6-member monocyclic heteroaryl comprising 1 or 2 heteroatoms that are N, wherein said aryl or heteroaryl is either unsubstituted or optionally independently substituted with 1 or more substituents which can be the same or different and are independently selected from the group consisting of halogen, alkyl, and -alkoxy;
- and
- R2 is a substituted or unsubstituted 8-10 membered fused polycyclic aryl or heteroaryl, wherein R2 is optionally substituted with 1 or more substituents which can be the same or different and are independently selected from the group consisting of halogen, alkyl and -alkoxy.
1 more element
A compound of formula (I-B)
- or a pharmaceutically acceptable salt thereof, wherein
- Ar1 is
- Re is selected from the group consisting of hydrogen, and halogen;
- and
- R2 is a substituted or unsubstituted 9-membered 6,5 bicyclic heteroaryl and said heteroaryl has 1, 2, 3, or 4 heteroatoms and said heteroatoms are independently O, S, or N, wherein R2 is optionally substituted with 1 or more substituents which can be the same or different and are independently selected from the group consisting of halogen, alkyl and -alkoxy.
2 more elements
A compound of formula (I-B)
- or a pharmaceutically acceptable salt thereof, wherein
- Ar1 is
- Re is selected from the group consisting of hydrogen, and fluoro;
- and
- R2 is selected from the group consisting of:
- and
3 more elements
Dependencies are inferred from the claim text.