P2X4 receptor antagonist

A compound of the following formula (I), a tautomer or a stereoisomer of the compound, or a pharmacologically acceptable salt thereof:

• wherein, in the formula, R1, R2 and R3 may be the same or different, and represent hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms and substituted with 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms and substituted with 1 to 3 halogen atoms, a halogen atom, hydroxyl group, nitro group, cyano group, amino group, an alkylamino group having 1 to 8 carbon atoms, or a dialkylamino group having 2 to 8 carbon atoms,
• X represents C or N,
• Y represents N or C(═O),
• provided that when X is C, Y represents N, and
• when X is N, Y represents C(═O),
• the double line consisting of the solid line and the broken line represents a single bond or double bond,
• n represents an integer of 0 to 6,
• Z represents O, S, or an atomic bond, and
• A represents pyridine ring having the same or different 1 to 5 substituents selected from N(R4)(R5), as a substituent, wherein R4 and R5 may be the same or different, and represent an alkyl group having 1 to 8 carbon atoms.